{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T12:50:09Z","timestamp":1781268609513,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An oral appliance (OA) can alleviate upper airway obstruction by pulling the mandible forward during sleep. While a large mandibular advancement with an OA decreases the number of apnea and hypopnea events, long\u2010term use may cause side effects, such as toothache, stiffness, and pain in the temporomandibular joint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objetives<\/jats:title><jats:p>This study aimed to evaluate the effectiveness of different mandibular positions for obstructive sleep apnea (OSA) and determine the optimal therapeutic mandibular position.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two patients (17 males and 15 females) with mild to moderate OSA participated in this prospective study. All patients were randomly allocated to receive a 50% mandibular advancement or a 75% mandibular advancement with an OA. The pre\u2010 and posttreatment apnea\u2010hypopnea index (AHI), apnea index (AI), and Epworth Sleepiness Scale (ESS) were compared. Treatment effectiveness and treatment success were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AHI improved significantly in both groups, and AI improved significantly in the group with 50% mandibular advancement. No significant improvements in the ESS were observed in either group. There was no significant difference in treatment effectiveness between groups. In the proportion of females and males whose treatment was effective in the two groups, females were significantly greater than males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For patients with mild to moderate OSA, 50% mandibular advancement is recommended as the initial therapeutic mandibular position. It was suggested that gender differences also affect treatment effectiveness.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.650","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T08:39:20Z","timestamp":1661243960000},"page":"1567-1574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The comparison of two different mandibular positions for oral appliance therapy in patients with obstructive sleep apnea"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7198-9894","authenticated-orcid":false,"given":"Eri","family":"Makihara","sequence":"first","affiliation":[{"name":"Division of Occlusion &amp; Maxillofacial Reconstruction, Department of Oral Function Kyushu Dental University Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Occlusion &amp; Maxillofacial Reconstruction, Department of Oral Function Kyushu Dental University Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Ogusu","sequence":"additional","affiliation":[{"name":"Division of Occlusion &amp; Maxillofacial Reconstruction, Department of Oral Function Kyushu Dental University Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010Ichi","family":"Masumi","sequence":"additional","affiliation":[{"name":"Division of Occlusion &amp; Maxillofacial Reconstruction, Department of Oral Function Kyushu Dental University Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-009-0298-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.5.387"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27485"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-015-1307-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9706079"},{"key":"e_1_2_10_7_1","first-page":"65","volume-title":"Designing clinical research","author":"Browner W. 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