{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:01:36Z","timestamp":1740175296794,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This analysis examined the clinical and histopathological characteristics of white and red oral mucosal lesions and patient lifestyle behaviors to understand how the lesions changed over 19\u201323 years, including among patients who developed oral and pharyngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Seventy\u2010five individuals with red and\/or white oral mucosal lesions with clinical diagnoses of smokeless tobacco lesions, leukoplakia, erythroplakia, lichen planus, ulcer, and virus\u2010associated lesions were identified in six Veterans Affairs Medical Center Dental Clinics (VAMC) from 1996 to 2001. Biopsy results and patients'\u00a0sociodemographic, medical, and tobacco\/alcohol use characteristics were obtained. Study dentists used standardized forms to capture information about the lesions. Study participants were re\u2010examined at intervals through January 2002. In 2020, a retrospective review of VAMC and public records ascertained whether participants developed oral cancer or died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common red or white oral mucosal lesions among the 75 study participants were leukoplakia (36.0%), smokeless tobacco lesions (26.7%), virus\u2010associated lesions (18.7%), and lichen planus (16.0%). Lesions in 11% of participants with leukoplakia and one\u2010third of participants with lichen planus persisted for 5\u00a0years or more. Dysplasia was present in four participants with leukoplakia. Seventeen percent of participants developed a new white or red oral mucosal lesion. Five patients (6.1%) developed oral or pharyngeal cancer, four among participants with leukoplakia (one with prior dysplasia) and one among participants with lichen planus. Four of the cancers developed 6\u201320 years after enrollment, and only one was at the original lesion site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The occurrence of oral and pharyngeal cancers in some study participants with white and red oral mucosal lesions many years after enrollment reinforces the need for patients, dentists, and health care systems to have better methods to identify and assess the malignant potential of oral lesions, monitor patients over time, and intercept high\u2010risk oral lesions before they become cancerous.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.677","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T06:44:00Z","timestamp":1670913840000},"page":"82-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Follow\u2010up study of veterans with white and red oral mucosal lesions at Veterans Affairs Dental Clinics"],"prefix":"10.1002","volume":"9","author":[{"given":"Robert S.","family":"Redman","sequence":"first","affiliation":[{"name":"VA Medical Center Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott R.","family":"Diehl","sequence":"additional","affiliation":[{"name":"Rutgers School of Dental Medicine Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trina","family":"Jones\u2010Richardson","sequence":"additional","affiliation":[{"name":"VA Medical Center Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeka G.","family":"Silva","sequence":"additional","affiliation":[{"name":"VA Medical Center San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Ko","family":"Yeh","sequence":"additional","affiliation":[{"name":"Audie L. Murphy Division South Texas Veterans Health Care System San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Malley","sequence":"additional","affiliation":[{"name":"VA Medical Center Danville Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam E.","family":"Farish","sequence":"additional","affiliation":[{"name":"VA Medical Center Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary B.","family":"Duffy","sequence":"additional","affiliation":[{"name":"VA Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Craig","sequence":"additional","affiliation":[{"name":"VA Medical Center San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1757-1489","authenticated-orcid":false,"given":"Deborah M.","family":"Winn","sequence":"additional","affiliation":[{"name":"National Cancer Institute Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.03.012"},{"volume-title":"Tobacco use and cessation","year":"2021","author":"American Dental Association","key":"e_1_2_9_3_1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-20-0234"},{"volume-title":"Clinical cessation tools","year":"2021","author":"Centers for Disease Control and Prevention","key":"e_1_2_9_5_1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz238"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-23499-6_22"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240560404"},{"issue":"18","key":"e_1_2_9_9_1","first-page":"4855","article-title":"Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis","volume":"54","author":"Greenblatt M. S.","year":"1994","journal-title":"Cancer Research"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01216-18"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.147096"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.08.011"},{"volume-title":"IARC monographs on the evaluation of carcinogenic risks to humans. 100E","year":"2012","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","key":"e_1_2_9_13_1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03322-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910600406"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2017.08.045"},{"key":"e_1_2_9_17_1","first-page":"CD001829","article-title":"Interventions for treating oral leukoplakia to prevent oral cancer","volume":"7","author":"Lodi G.","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"volume-title":"Precision optical guidance for oral biopsy based on next generation hallmarks of cancer.\u00a0Grant No. R01DE029590. (Internet)","year":"2021","author":"Richards\u2010Kortum R. R.","key":"e_1_2_9_18_1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01007-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0276"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.03.008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104850"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2013.12.008"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphd.12521"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3496"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2007.tb01746.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2004.0403"},{"key":"e_1_2_9_28_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. (2020).SEER*Stat Database: Incidence\u2014SEER 21 Regs Research Data\u2009+\u2009Hurricane Katrina Impacted Louisiana Cases Nov Sub (2000\u20132018) National Cancer Institute DCCPS Surveillance Research Program Surveillance Systems Branch released April 2021 based on the November 2020 submission. (Internet).\u00a0(www.seer.cancer.gov)."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12538"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103270"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13087"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13704"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12339"},{"volume-title":"National Health and Nutrition Examination Survey III Oral Examination Component","year":"1992","author":"Westat, Inc","key":"e_1_2_9_34_1"},{"issue":"7","key":"e_1_2_9_35_1","first-page":"CD010276","article-title":"Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions","volume":"7","author":"Walsh T.","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-15-0091"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.677","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cre2.677","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T22:06:21Z","timestamp":1692309981000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/cre2.677"],"URL":"https:\/\/doi.org\/10.1002\/cre2.677","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"type":"print","value":"2057-4347"},{"type":"electronic","value":"2057-4347"}],"subject":[],"published":{"date-parts":[[2022,12,12]]},"assertion":[{"value":"2022-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}