{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:00:28Z","timestamp":1783576828500,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Salivary adenoid cystic carcinoma (SACC) is one of the most common salivary gland tumors in which patients encounter local recurrence and lung metastases. Understanding prognostic biomarkers in SACC is essential for future development in prognosis and treatment. This study aimed to assess the expression level of vascular endothelial growth factor (VEGF) and its potential regulatory microRNAs in SACC for prognostic determination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material\u00a0and Methods<\/jats:title><jats:p>The expression of VEGF in SACC samples was assessed using immunohistochemistry. Potential regulatory microRNAs were evaluated using quantitative reverse transcription\u2010polymerase chain reaction. Associations between VEGF and microRNAs expression and clinicopathological parameters were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VEGF expression levels positively correlated with histologic grade (<jats:italic>p<\/jats:italic>\u2009=\u2009.004) and treatment modality (<jats:italic>p<\/jats:italic>\u2009=\u2009.04). Decreased expression of miR\u201029a (<jats:italic>p<\/jats:italic>\u2009=\u2009.01) and increased expression of miR\u201093\u20105p and miR\u2010205 (both <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) were observed in SACC compared to normal salivary gland tissue. MiR\u201093\u20105p showed a positive association (<jats:italic>p<\/jats:italic>\u2009=\u2009.02) with VEGF overexpression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results showed the downregulation of miR\u201029 and overexpression of miR\u201093 and miR\u2010205 in the SACC group, and the correlation between miR\u201093 and\u00a0VEGF suggests these biomarkers as potential prognostic markers in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.678","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T07:29:10Z","timestamp":1666682950000},"page":"112-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Interactive role of miR\u201029, miR\u201093, miR\u2010205, and VEGF in salivary adenoid cystic carcinoma"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5845-1598","authenticated-orcid":false,"given":"Parisa","family":"Bayat","sequence":"first","affiliation":[{"name":"School of Dentistry, Dentistry Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0691-1580","authenticated-orcid":false,"given":"Nazanin","family":"Mahdavi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3885-2914","authenticated-orcid":false,"given":"Shima","family":"Younespour","sequence":"additional","affiliation":[{"name":"School of Dentistry, Dentistry Research Institute Tehran University of Medical Sciences Tehran 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