{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:22:08Z","timestamp":1793049728910,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015027","name":"Vice Chancellor for Research and Technology, Hamadan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>One of the simplest methods to increase keratinized gingiva is the modified apically repositioned flap (MARF) technique. In this method, the periosteum remains exposed, which may lead to postoperative pain and discomfort. In the presence of bone dehiscence, bone resorption\u00a0and gingival recession may occur. Hence, this study aims to use platelet\u2010rich fibrin (PRF) to promote wound healing in the MARF technique and overcome its disadvantages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In this randomized controlled trial study, 10 patients (six males and four\u00a0females with a mean age of 33.9\u2009\u00b1\u200911.13) with less than 2\u2009mm of attached gingiva bilaterally were treated by the MARF\u2009+\u2009PRF membrane (test group), on the\u00a0one hand, whereas, on the other hand, it was treated only by MARF (control group). Clinical parameters of keratinized gingiva include thickness, width, and vestibule depth before and 8 weeks after the intervention were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The attached gingival width increased significantly in both groups (1.7\u2009mm in the MARF and 2.3\u2009mm in the PRF) and this was greater in the PRF group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Gingival thickness in the PRF method was significantly higher than in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Probe depth, vestibular depth, and postoperative pain were not different in both groups. Wound shrinkage in the MARF group (51%) was significantly higher than in the PRF group (30%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using PRF with the MARF method significantly increased the width and thickness of the gingiva and reduced shrinkage compared to MARF only. Postoperative pain and vestibular depth changes were similar in both groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.693","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T04:06:31Z","timestamp":1669349191000},"page":"36-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of using platelet\u2010rich fibrin to increase keratinized tissue around the tooth in the modified apical reposition flap method: A split\u2010mouth, randomized controlled trial"],"prefix":"10.1002","volume":"9","author":[{"given":"Parviz","family":"Torkzaban","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2176-9786","authenticated-orcid":false,"given":"Nazli","family":"Rabienejad","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9041-559X","authenticated-orcid":false,"given":"Zahra","family":"Cheraghi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Hamadan University of Medical Science  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2303-5471","authenticated-orcid":false,"given":"Kamran","family":"Lahoorpoor","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-09-00035.1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2020.3165"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2020.02.020"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03702-w"},{"issue":"2","key":"e_1_2_12_6_1","first-page":"323","article-title":"Width of keratinized gingiva and the health status of the supporting tissues around dental implants","volume":"23","author":"Bouri A","year":"2008","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02475.x"},{"issue":"3","key":"e_1_2_12_8_1","first-page":"265","article-title":"The modified apically repositioned flap to increase the dimensions of attached gingiva: The single incision technique for multiple adjacent teeth","volume":"26","author":"Carnio J.","year":"2006","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060414"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2386"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.4241"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.9.1110"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.011"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.012"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-017-0767-9"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050393"},{"issue":"1","key":"e_1_2_12_17_1","first-page":"1","article-title":"Word of caution: Negative impact of mouthwashes on folded Platelet\u2010Rich Fibrin (F\u2010PRF) membrane viability","volume":"8","author":"Cs\u00f6nge L.","year":"2021","journal-title":"International Journal of Dentistry and Oral Health"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.2.71"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1962.33.4.328"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2021.01.006"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-017-0371-8"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.34172\/ajdr.2021.10"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.138699"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.10.623"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-020-00486-z"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb01226.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","unstructured":"Miller P. 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