{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:23:11Z","timestamp":1790007791675,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oxidative stress, an imbalance between the body's natural antioxidant defenses and the production of reactive oxygen species (ROS), can result in serious oral diseases, including oral cancer, periodontal diseases, and oral lichen planus, through the activation of the redox\u2010sensitive transcription factors and inflammation. The purpose of this study was to assess the potential effects of a removable complete denture on the levels of oxidative stress markers, such as lipid peroxidation (MDA), advanced oxidation protein products (AOPP), and catalase, and the quantitative expression of the redox\u2010sensitive transcription factor NF\u2010<jats:italic>\u03ba<\/jats:italic>B p65 subunit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This interventional follow\u2010up study enrolled 40 participants of both sexes aged 28\u201378 years, with a median age of 56 years, where unstimulated saliva was collected before denture placement, immediately after the denture placement, and 24\u2009h, 7 days, and 30 days after the denture placement. The most prominent ROS overproduction was reported on the seventh day (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), followed by a significant fall in antioxidative defense.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The NF\u2010<jats:italic>\u03ba<\/jats:italic>B p65 subunit, whose expression pattern was highest in the same time period on the seventh day, serves as a signaling molecule for redox imbalance due to ROS production. Over the next 30 days, its levels remained moderately increased compared to the basal value, which may influence pro\u2010inflammatory pathways and the integrity of oral tissue components. These alterations may be induced by the dentures, which can produce high pressures on the supporting tissues or by the synthetic materials used for producing the dentures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our research may help to clarify the potential pathways by which oxidative stress and redox\u2010sensitive inflammatory mediators, as well as mechanical and chemical irritants, may serve as risk factors for premalignant lesions in the mouth. Further research on this topic is required to understand the molecular mechanisms behind the relationship between inflammation and oral premalignant lesions caused by mechanical and chemical irritation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70007","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T07:35:05Z","timestamp":1726731305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Influence of Removable Complete Denture on Pro\u2010Oxidant Antioxidant Balance and Redox\u2010Sensitive Inflammation Biomarker NF\u2010<i>\u0138<\/i>B in the Oral Cavity: An Interventional Follow\u2010Up Study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6192-6016","authenticated-orcid":false,"given":"Mirjana","family":"Bo\u0161kovi\u0107","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Medical Faculty University of Ni\u0161 Nis Nis region Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-6428","authenticated-orcid":false,"given":"Du\u0161an","family":"Sokolovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical Faculty University of Ni\u0161 Nis Nis region Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-6110","authenticated-orcid":false,"given":"Sa\u0161a","family":"Stankovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Medical Faculty University of Ni\u0161 Nis Nis region Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8472-0934","authenticated-orcid":false,"given":"Ivan","family":"Risti\u0107","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Medical Faculty University of Ni\u0161 Nis Nis region Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4660-6171","authenticated-orcid":false,"given":"Jordan","family":"Popovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology and Immunology, Institute of Odontology The Sahlgrenska Academy at University of Gotheburg Goteborg Goteborg region Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-2466","authenticated-orcid":false,"given":"Gordana","family":"Koci\u0107","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical Faculty University of Ni\u0161 Nis Nis region Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1588507"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01091.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00669.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.296"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-005-1579-7"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.02.013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290301x.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.147105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/45794"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geu043"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.02.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23932"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-007-0162-8"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(91)90067-M"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-123825"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.05.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-008-0202-z"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01143.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2006.tb03827.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.278.3.C451"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20570"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.621"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2011.133"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41971"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.03.019"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.2020033210"},{"issue":"4","key":"e_1_2_10_29_1","first-page":"241","article-title":"Saliva: An Emerging Biofluid for Early Detection of Diseases","volume":"22","author":"Lee Y. H.","year":"2009","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.10.016"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22262"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1331"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011215)92:12<3037::AID-CNCR10171>3.0.CO;2-#"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.10.026"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.20"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2015.1021834"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.09.006"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2011.02216.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608501001"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2355"},{"issue":"20","key":"e_1_2_10_43_1","first-page":"20","article-title":"Potential Co\u2010Relation Between Chronic Periodontitis and Cancer\u2014An Emerging Concept","volume":"1","author":"Shrihari T. G.","year":"2016","journal-title":"Gulf Journal of Oncology"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.203510"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130066"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200202"},{"issue":"2","key":"e_1_2_10_48_1","first-page":"240","article-title":"New Insights on Oxidative Stress in Cancer","volume":"12","author":"Visconti R.","year":"2009","journal-title":"Current Opinion in Drug Discovery & Development"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.09.003"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.04.005"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.1.207"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.04.018"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T11:44:24Z","timestamp":1728042264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/cre2.70007"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70007","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,19]]},"assertion":[{"value":"2023-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70007"}}