{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:36:47Z","timestamp":1785832607032,"version":"3.56.0"},"reference-count":66,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Metastasis to the oral soft tissues and jaw is rare and accounts for 1%\u20133% of maxillofacial malignancies. These lesions usually occur in the context of an extensive malignant tumor with a poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Archived cases from the Oral and Maxillofacial Pathology Department of the Faculty of Dentistry and two hospital centers of Mashhad University of Medical Sciences were examined. Inclusion criteria were cases with available records of pathologically confirmed metastatic lesions of the oral cavity with or without diagnosed primary malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Metastatic lesions in the oral cavity and jaw were found in 18 patients, including seven women and 11 men, with a mean age of 49.5 years. Metastatic lesions were more common in the jaw (66%) and particularly in the mandible (38%) than elsewhere. In the case of soft tissue metastases, the gingiva was more affected than other sites. The primary tumor was most commonly in the kidney in men and in the breast in women (36%\u201328%). In addition, the diagnosis of a metastatic lesion led to the detection of the primary tumor elsewhere in six out of 18 cases (33.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early diagnosis of the lesions is challenging, given the absence of specific signs or symptoms, which, in some cases, nonetheless resemble inflammatory, benign, reactive lesions. Therefore, dentists play a crucial role in diagnosing such lesions, as they lead to the discovery of hidden distant primary tumors. Biopsy should always be considered for suspicious lesions, even if the probability is very low.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70011","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T06:40:04Z","timestamp":1729233604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tumor Metastasis to the Oral Soft Tissues and Jaw Bones: A Retrospective Study and Review of the Literature"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0480-6442","authenticated-orcid":false,"given":"Atessa","family":"Pakfetrat","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Diseases Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5898-3180","authenticated-orcid":false,"given":"Zohreh","family":"Dalirsani","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-0086","authenticated-orcid":false,"given":"Nasrollah","family":"Saghravanian","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1080-1907","authenticated-orcid":false,"given":"Kazem","family":"Anvari","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Oncology and Cancer Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5211-6956","authenticated-orcid":false,"given":"Sajede","family":"Asalian","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-0340","authenticated-orcid":false,"given":"Armaghan","family":"Salehi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Dentistry Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboobeh","family":"Taherizadeh","sequence":"additional","affiliation":[{"name":"School of Health Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"References marked with * are available in Supplementary Information File."},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.01.008"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.06.029"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.5648"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130118"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(90)90388-I"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0123-4"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194007000-00016"},{"key":"e_1_2_13_10_1","first-page":"733","article-title":"\u00c0 Propos Des Tumeurs M\u00e9tastatiques De La Cavit\u00e9 Buccale Et Des Maxillaires","volume":"200","author":"Bertoin P.","year":"1997","journal-title":"Actualit\u00e9s Odonto\u2010Stomatologiques"},{"issue":"2","key":"e_1_2_13_11_1","first-page":"132","article-title":"Metastatic Tumors to the Jaws: A Report of Eight New Cases","volume":"11","author":"Bodner L.","year":"2006","journal-title":"Medicina Oral, Patologia Oral Y Cirugia Bucal"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.272"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27041"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1963.tb05105.x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0931"},{"issue":"112","key":"e_1_2_13_16_1","first-page":"327","article-title":"Metastasis of Colon Adenocarcinoma to Maxillary Gingiva and Palate","volume":"32","author":"Dalirsani Z.","year":"2020","journal-title":"Iranian Journal of Otorhinolaryngology"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0112"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3611"},{"issue":"5","key":"e_1_2_13_19_1","first-page":"1819","article-title":"Mental Neuropathy (Numb Chin Syndrome) Leading to Diagnosis of Metastatic Mediastinal Cancer","volume":"30","author":"Friedrich R. 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