{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:38:45Z","timestamp":1788194325299,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to evaluate the periodontal condition adjacent to Cention N (CN) restorations applied for noncarious cervical lesions (NCCL) compared with resin\u2010modified glass ionomer cement (RM\u2010GIC) restorations in terms of plaque accumulation, attachment loss, and gingival inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This is a double\u2010blind split\u2010mouth three\u2010armed randomized\u2010controlled clinical trial. The study arms are RM\u2010GIC (FUJI II LC), CN\u2009+\u2009adhesive system, and CN\u2009+\u2009retentive groove. The study included 25 restorations per arm. Follow\u2010ups were performed at 1 week, 3, 6, and 9 months after the application of the restorations. The periodontal condition was evaluated using the plaque index (PI), the bleeding on probing index (BOP), and the probing depth (PD). Appropriate tests were used to perform statistical analyses (<jats:italic>\u03b1<\/jats:italic>\u2009=\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference between Cention N and RM\u2010GIC regarding the studied variables. However, after the application of the restorations, it was noted that the PI and the PD mean values increased. The average increase after 9 months was 0.06 and 0.34 for PI and PD, respectively, with that of PD being significant. It was also noted that the percentage of positive BOP sites increased at the 1\u2010week follow\u2010up for all study groups and afterward dropped to near preintervention values at the 3\u2010month and later follow\u2010ups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The two ion\u2010releasing materials Cention N and RM\u2010GIC have a comparable and clinically acceptable effect on the gingival tissue when restoring NCCLs. The combined effect of the gingival retraction cord and the rubber dam clamp on the periodontal tissues might be more important to consider, especially in relation to the probing depth. Future long\u2010term studies are needed to evaluate the effect of Cention N on the subgingival biofilm in comparison with nonion\u2010releasing restorative materials, and subsequently, its effect on gingival inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p>This clinical trial was registered in <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrial.gov\">clinicaltrial.gov<\/jats:ext-link> clinical registry under protocol #NCT05593159.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70025","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T05:50:02Z","timestamp":1728885002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Periodontal Evaluation for a New Alkasite Restorative Material in Noncarious Cervical Lesions: A Randomized\u2010Controlled Clinical Trial"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4472-3334","authenticated-orcid":false,"given":"Khattab","family":"Mustafa","sequence":"first","affiliation":[{"name":"Faculty of Philosophy and Social Sciences University of Augsburg Augsburg Germany"},{"name":"Faculty of Dental Medicine Damascus University Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaith","family":"Alfakhry","sequence":"additional","affiliation":[{"name":"Department of Education University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussam","family":"Milly","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine Damascus University Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4034\/PBOCI.2019.191.129"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcd.jcd_336_21"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e03969"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.a40295"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01705.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2023.104549"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1991.tb01017.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1991.tb01134.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2020.103571"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-3327.363534"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.13585"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.a36885"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym15030650"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10020284"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350260248210"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2033"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.09.011"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060380"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2003.00378.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.52831"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2003.01277.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00472.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.4.422"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.65436"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2020.103474"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070032"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12142"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12142"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2020.103285"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2019.10.004"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.a41976"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02354-4"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T17:24:46Z","timestamp":1734629086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,13]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/cre2.70025"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70025","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,13]]},"assertion":[{"value":"2024-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70025"}}