{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:07:38Z","timestamp":1771632458205,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Atrial fibrillation (AF) and stroke are two highly related conditions, with periodontitis and periodontal pathogens, such as <jats:italic>Porphyromonas gingivalis<\/jats:italic> (Pg), appearing to be the most prominent common risk factors. In this study, we evaluated studies assessing Pg infection via serum\/plasma anti\u2010Pg antibodies in patients with AF and\/or stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Online databases (PubMed, Scopus, Embase, and the Web of Science) were screened for studies showing the association between anti\u2010Pg antibodies with stroke and\/or AF. Relevant data were extracted, and a subsequent random\u2010effects meta\u2010analysis was performed to calculate the pooled odds ratio (OR) or standardized mean difference (SMD) and 95% confidence intervals (CIs) for Pg seropositivity or anti\u2010Pg antibody levels in stroke patients compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen studies were included in the systematic review. Based on the meta\u2010analysis performed, there was no significant difference in Pg IgA and IgG levels between patients with stroke and controls (IgA: SMD 0.11, 95% CI \u22120.02 to 0.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.1; IgG: SMD \u22120.12, 95% CI \u22121.24 to 0.99, <jats:italic>p<\/jats:italic>\u2009=\u20090.83). Similarly, no difference was observed between these groups in terms of Pg IgA and IgG seropositivity (IgA: OR 1.63, 95% CI 1.06\u20132.50, <jats:italic>p<\/jats:italic>\u2009=\u20090.026; IgG: OR 2.30, 95% CI 1.39\u20133.78, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Subsequently, we reviewed the results of six articles investigating serum or plasma IgG antibodies against Pg in patients with AF. Our results revealed a strict association between Pg infection and AF, with AF patients exhibiting either higher anti\u2010Pg antibody levels or a higher prevalence of positive serum Pg antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study supports the clinical utility of Pg infection assessment in patients with periodontitis and those with AF and solicits more focused studies to corroborate its use in clinical settings to enhance overall outcomes, reduce the risk of complications like stroke, and help fine\u2010tune personalized therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70041","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T11:43:26Z","timestamp":1731498206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti\u2010<i>Porphyromonas gingivalis<\/i> Antibody Levels in Patients With Stroke and Atrial Fibrillation: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"10","author":[{"given":"Alessandro","family":"Cannavo","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nastaran","family":"Babajani","sequence":"additional","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences Tehran Iran"},{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behrad","family":"Saeedian","sequence":"additional","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences Tehran Iran"},{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Ghondaghsaz","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Rengo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirmohammad","family":"Khalaji","sequence":"additional","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences Tehran Iran"},{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-4227","authenticated-orcid":false,"given":"Amir 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