{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:36:18Z","timestamp":1788212178761,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Peri\u2010implantitis (PI) is the most common biological issue surrounding dental implants. According to current knowledge, the aforementioned complication is not equally distributed across different populations, and gene polymorphisms might be one contributing factor. The current study aimed to examine the association between gene polymorphisms of matrix metalloproteinase\u2010 (MMP\u2010) 1, \u20102, \u20103, \u20107, and \u201013 with PI in an Iranian demographic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The study's sample included 50 subjects suffering from PI and 89 healthy controls. From each participant, a venous blood sample of 5\u2009cc was obtained, and DNA was extracted. Gene polymorphisms were investigated using restriction fragment length polymorphism polymerase chain reaction (RFLP\u2010PCR) combined with electrophoresis. Statistical analyses were done using the Pearson chi\u2010square test, odds ratio, and <jats:italic>t<\/jats:italic>\u2010test via SPSS version 28.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MMP\u20103 (\u20101171 5A\/6A) and MMP\u20107 (\u2010181 A\/G) gene polymorphisms were significantly different between the patients with PI and healthy controls (PV\u2009&lt;\u20090.001 and =0.025, respectively). MMP\u20101 (\u20101607 1G\/2G), MMP\u20102 (\u20101306 C\/T), and MMP\u201013 (\u201077 A\/G) gene polymorphisms did not, however, differ in terms of prevalence between the two groups (PV\u2009&gt;\u20090.05). Moreover, the presence of the 6\u2009A allele in the MMP\u20103 (\u20101171 5A\/6A) genotype resulted in a significant decrease in PI risk (PV\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gene polymorphisms in the genotypes of MMP\u20103 (\u20101171 5A\/6A) and MMP\u20107 (\u2010181 A\/G) were differential when comparing PI patients and healthy controls of the studied population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70049","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T05:16:17Z","timestamp":1732857377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Association of Matrix Metalloproteinase\u20101, \u20102, \u20103, \u20107, and \u201013 Gene Polymorphisms With Peri\u2010Implantitis in an Iranian Population: A Case\u2013Control 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Epidemiology and Biostatistics, Faculty of Health Qom university of Medical Sciences Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5187-3261","authenticated-orcid":false,"given":"Saharnaz","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Dental Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4958-4401","authenticated-orcid":false,"given":"Shirin","family":"Lotfipanah","sequence":"additional","affiliation":[{"name":"Department of Biology Education Farhangian University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-3928","authenticated-orcid":false,"given":"Reza","family":"Amid","sequence":"additional","affiliation":[{"name":"Dental Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Iranian Center for Endodontic Research, Research, Institute for Dental Sciences, Dental School Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-2791","authenticated-orcid":false,"given":"Mahdi","family":"Kadkhodazadeh","sequence":"additional","affiliation":[{"name":"Dental Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Iranian Center for Endodontic Research, Research, Institute for Dental Sciences, Dental School Shahid Beheshti University of Medical Sciences Tehran 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