{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:47:11Z","timestamp":1787669231157,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014903","name":"Osteo Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Nonsteroidal anti\u2010inflammatory drugs (NSAIDs) are often prescribed following the placement of dental implants, but the effects of these drugs on the osseointegration process are poorly understood. We designed a randomized, placebo\u2010controlled pilot study to quantitatively assess the effect of NSAIDs during early implant osseointegration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Subjects receiving a maxillary dental implant were randomized to take naproxen or placebo for 7 days after the surgery. Implant osseointegration was quantified using Resonance Frequency Analysis device. Implant\u2010Stability\u2010Quotient (ISQ) measurement was performed at the time of surgery and at follow\u2010up visits 1, 4, and 16 weeks after surgery. Periapical radiographs were taken to measure the marginal bone level. Separately, a questionnaire of NSAIDs usage was provided to subjects presenting with early implant failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 4 weeks, ISQ values increased modestly (\u2009+\u20091%) in subjects receiving naproxen whereas subjects receiving placebo had a much larger increase in ISQ value (+41%). We observed 55% more marginal bone loss at 4 weeks, and 52% at 16 weeks in the naproxen group compared to the placebo group. These results were not found to have statistically significant between groups (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.05). These effect sizes and variance were used to conduct a power analysis to determine the necessary sample size for future studies. Furthermore, our separate questionnaire study revealed that 68% of our patients with early failed dental implants reported a history of NSAIDs usage after the surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, this pilot study provides effect sizes and sample size estimates for future studies to definitively determine recommendations regarding NSAID usage following dental implant surgery. Nonetheless, our study did not observe any statistically significant differences in ISQ value or marginal bone loss after up to 16 weeks of follow\u2010up between subjects from naproxen and placebo groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70065","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T07:21:13Z","timestamp":1736148073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Randomized, Placebo\u2010Controlled Pilot Study of Naproxen During Dental Implant Osseointegration"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8507-8728","authenticated-orcid":false,"given":"Hattanas","family":"Kumchai","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Thomas Jefferson University Philadelphia Pennsylvania USA"},{"name":"Department of Oral and Maxillofacial Surgery Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel I.","family":"Taub","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan E.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Thomas Jefferson University Philadelphia Pennsylvania USA"},{"name":"Department of Oral and Maxillofacial Surgery Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844317009038440"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/OI9.0000000000000092"},{"issue":"5","key":"e_1_2_10_4_1","first-page":"449","article-title":"The Effect of Implant Length and Diameter on the Primary Stability in Different Bone Types","volume":"10","author":"Barikani H.","year":"2013","journal-title":"Journal of Dentistry (Tehran, Iran)"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2010.02117.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844316909036699"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200401000-00017"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.10.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12157"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2016-000550"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32836200b8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-13-00125"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1556\/imas.5.2013.4.3"},{"issue":"5","key":"e_1_2_10_14_1","first-page":"845","article-title":"A Double\u2010Blind, Randomized Study of Naproxen Sodium, Ibuprofen, and Placebo in Postoperative Dental Pain","volume":"15","author":"Kiersch T. A.","year":"1993","journal-title":"Clinical Therapeutics"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2017.47.4.231"},{"issue":"11","key":"e_1_2_10_16_1","first-page":"985","article-title":"Fracture Healing and NSAIDs","volume":"60","author":"Lam C.","year":"2014","journal-title":"Canadian Family Physician Medecin de famille canadien"},{"issue":"3","key":"e_1_2_10_17_1","first-page":"1","article-title":"American Society of Interventional Pain Physicians (ASIPP) Guidelines for Responsible Opioid Prescribing in Chronic Non\u2010Cancer Pain: Part I \u2014 Evidence Assessment","volume":"15","author":"Manchikanti L.","year":"2012","journal-title":"Pain Physician"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","unstructured":"Mitchell J. A. P.Akarasereenont C.Thiemermann R. J.Flower andJ. R.Vane\u201cSelectivity of Nonsteroidal Antiinflammatory Drugs as Inhibitors of Constitutive and Inducible Cyclooxygenase.\u201dProceedings of the National Academy of Sciences.1993;90(24):11693\u201311697.","DOI":"10.1073\/pnas.90.24.11693"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.07.021"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2007.698"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-5688-5_1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200702001s08"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12149"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12493"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:57:48Z","timestamp":1748843868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,5]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/cre2.70065"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70065","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,5]]},"assertion":[{"value":"2024-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70065"}}