{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:46:08Z","timestamp":1753868768802,"version":"3.41.2"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Central giant cell granuloma (CGCG) is a rare benign tumor. Extended aggressive lesions require large resections, which can lead to bone defects and tooth loss. Rehabilitative treatment is necessary to restore good aesthetics and function. However, the protocol for implant treatment post\u2010CGCG is still unclear. The objective of this scoping review is to shed light on the rehabilitation protocol for CGCG sites by outlining the relevance and timing of implant surgery and prosthetic rehabilitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The review followed the Preferred Reporting Items for Systematic Review and Meta\u2010Analyses statement and searched databases for data published between 1999 and 2023. The scoping review aimed to answer the question: \u201cIn patients with a diagnosed and treated CGCG, able to receive an implant, does the CGCG tumor recur before or after implant surgery\u201d? Only articles that described cases where patients with a diagnosed CGCG received an implant in a site previously affected by CGCG were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The review describes seven case reports and one case series that discuss implantology\u2010driven restoration after CGCG exeresis in humans. The patients, aged between 7 and 80 years, underwent surgical removal of CGCG and received implant\u2010supported prosthetic rehabilitation. A total of 34 implants were placed between 4 and 60 months after the tumor\u2010resection surgery. No recurring lesions were observed during the follow\u2010up period, which ranged between 2 and 12 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on the limited evidence available, it appears that implant placement after CGCG removal is safe after a minimum of 4 months of healing. However, further research is necessary to confirm this conclusion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70085","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:15:00Z","timestamp":1739423700000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relevance and Timing of Implant\u2010Driven Rehabilitation in Central Giant Cell Granuloma Cases\u2014A Scoping Review"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-0400","authenticated-orcid":false,"given":"Roman","family":"Tatiana","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Dental Faculty University of Strasbourg Strasbourg France"},{"name":"INSERM UMR_S 1121, CNRS EMR 7003, Biomaterials and Bioengeneering University of Strasbourg Strasbourg France"},{"name":"P\u00f4le de M\u00e9decine et Chirurgie Bucco\u2010Dentaire, H\u00f4pital Civil, H\u00f4pitaux Universitaire de Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Thomas","sequence":"additional","affiliation":[{"name":"Private practice Lab\u00e8ge France"},{"name":"Former Intern Dental Faculty University of Lille Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leclercq","family":"Olivier","sequence":"additional","affiliation":[{"name":"Private practice Arras France"},{"name":"Formerly Department of Periodontology and Implantology, Dental Faculty University of Lille  France"},{"name":"Service d'Odontologie Abel Caumartin, P\u00f4les Sp\u00e9cialit\u00e9s M\u00e9dico\u2010chirurgicales, Centre Hospitalier Universitaire de Lille  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafash","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Private practice Arras France"},{"name":"Formerly Department of Periodontology and Implantology, Dental Faculty University of Lille  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kharouf","family":"Naji","sequence":"additional","affiliation":[{"name":"INSERM UMR_S 1121, CNRS EMR 7003, Biomaterials and Bioengeneering University of Strasbourg Strasbourg France"},{"name":"Department of Operative Dentistry and Endodontics, Dental Faculty University of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8870-4659","authenticated-orcid":false,"given":"Olivier","family":"Etienne","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Dental Faculty University of Strasbourg Strasbourg France"},{"name":"INSERM UMR_S 1121, CNRS EMR 7003, Biomaterials and Bioengeneering University of Strasbourg Strasbourg France"},{"name":"P\u00f4le de M\u00e9decine et Chirurgie Bucco\u2010Dentaire, H\u00f4pital Civil, H\u00f4pitaux Universitaire de Strasbourg Strasbourg France"},{"name":"Private practice Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boschin","family":"Francois","sequence":"additional","affiliation":[{"name":"Service d'Odontologie Abel Caumartin, P\u00f4les Sp\u00e9cialit\u00e9s M\u00e9dico\u2010chirurgicales, Centre Hospitalier Universitaire de Lille  France"},{"name":"Private practice Lille France"},{"name":"Department of Periodontology and Implantology, Dental Faculty University of Lille  France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_11_2_1","DOI":"10.1016\/j.tripleo.2005.04.014"},{"doi-asserted-by":"publisher","key":"e_1_2_11_3_1","DOI":"10.1111\/jicd.12342"},{"doi-asserted-by":"publisher","key":"e_1_2_11_4_1","DOI":"10.1186\/s12903-019-0983-2"},{"doi-asserted-by":"publisher","key":"e_1_2_11_5_1","DOI":"10.1016\/j.stomax.2009.06.002"},{"key":"e_1_2_11_6_1","article-title":"Long\u2010Term Clinical and Radiologic Documentation of a Maxillary Odontogenic Myxoma From Early Clinical Signs to Implant\u2010Supported Prosthodontic Rehabilitation: Case Report and Review of the Literature","volume":"48","author":"Berger S.","year":"2017","journal-title":"Quintessence International"},{"doi-asserted-by":"publisher","key":"e_1_2_11_7_1","DOI":"10.1155\/2015\/697673"},{"key":"e_1_2_11_8_1","first-page":"112","article-title":"Tratamiento Quir\u00fargico Y Reconstrucci\u00f3n Mandibular En Granuloma De C\u00e9lulas Gigantes","volume":"18","author":"Castillo\u2010Camacho M. 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