{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:46:07Z","timestamp":1753868767080,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate tooth development in patients with unilateral cleft lip and palate (UCLP) and unilateral cleft lip and alveolus (UCLA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A retrospective case\u2013control study was carried out; 180 panoramic radiographs (OPGs) from non\u2010syndromic patients (160 UCLP, 20 UCLA) treated at the University Medical Center Mainz (2019\u20132022) were analyzed. Patients were matched to a control group by calendar age, gender, and ethnicity. Inclusion criteria were verified through clinical data, photographs, and radiographs. No follow\u2010up was conducted for this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cleft group showed a significantly lower dental age compared to the control group (10.72\u2009\u00b1\u20092.65 vs. 11.41\u2009\u00b1\u20092.79; <jats:italic>p<\/jats:italic>\u2009=\u20090.017), with a mean difference of 0.69 years (95% CI: 0.13\u20131.25 years). Tooth development was slower on the cleft side (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and maxillary teeth lagged behind mandibular teeth (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The difference in the control group was somewhat smaller, with a mean difference of 0.11 degrees of mineralization in the control group compared to 0.25 degrees of mineralization in the cleft group. In UCLP patients, significant mineralization differences were noted for the lateral incisors (<jats:italic>p<\/jats:italic>\u2009=\u20090.004), the central incisor (<jats:italic>p<\/jats:italic>\u2009=\u20090.047), and canine (<jats:italic>p<\/jats:italic>\u2009=\u20090.030).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with unilateral clefts show delayed tooth development and dental age, particularly in the affected quadrant. In everyday treatment, attention should be paid to a later start of orthodontic tooth movement to avoid damaging the slower developing roots.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70086","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T08:45:21Z","timestamp":1740213921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in Tooth Development in Patients With Unilateral Cleft Lip and Palate"],"prefix":"10.1002","volume":"11","author":[{"given":"Marie","family":"Schwarting","sequence":"first","affiliation":[{"name":"Department of Orthodontics University Medical Center at the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Wehrbein","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Medical Center at the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Schmidtmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI) University Medical Center at the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1950-640X","authenticated-orcid":false,"given":"Christina","family":"Erbe","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Medical Center at the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8130-4214","authenticated-orcid":false,"given":"Susanne","family":"Wriedt","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Medical Center at the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665620984649"},{"issue":"3","key":"e_1_2_9_3_1","first-page":"304","article-title":"Timing of Dental Development in Saudi Cleft Lip and Palate Patients","volume":"35","author":"Bindayel N. A.","year":"2014","journal-title":"Saudi Medical Journal"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkJOrthod.2020.19094"},{"issue":"2","key":"e_1_2_9_5_1","first-page":"211","article-title":"A New System of Dental Age Assessment","volume":"45","author":"Demirjian A.","year":"1973","journal-title":"Human Biology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03573-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2001_038_0374_hatfig_2.0.co_2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/1679-775720130127"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2019.06.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500210"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1597\/08-275.1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.2536.310"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1597\/07-019"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1597\/07-077.1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(09)60695-4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1597\/06-054"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-022-00431-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjr074"},{"issue":"2","key":"e_1_2_9_19_1","first-page":"109","article-title":"Developmental Dental Changes in Isolated Cleft Lip and Palate","volume":"19","author":"Pham A. N.","year":"1997","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2004.00158.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ejo.a035974"},{"issue":"3","key":"e_1_2_9_22_1","first-page":"197","article-title":"Comparison of Tooth Formation in Noncleft and Cleft\u2010Affected Children With and Without Hypodontia","volume":"49","author":"Ranta R.","year":"1982","journal-title":"ASDC Journal of Dentistry for Children"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2002_039_0193_ddopli_2.0.co_2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2013.00053"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2019.09.010"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1992_029_0380_mliosw_2.3.co_2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2015.76.10.584"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665617750489"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12196"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/1677-3225v13n4a15"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1597\/06-218.1"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1998_035_0154_dpopap_2.3.co_2"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-017-0313-x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2000_037_0571_toadot_2.0.co_2"},{"key":"e_1_2_9_35_1","unstructured":"Wichelhaus A.Kieferorthop\u00e4die\u2014Therapie Band 1: Grundlegende Behandlungskonzepte.2013."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS15064J"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:56:49Z","timestamp":1748843809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/cre2.70086"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70086","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"type":"print","value":"2057-4347"},{"type":"electronic","value":"2057-4347"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70086"}}