{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:46:07Z","timestamp":1753868767266,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This case series evaluated the clinical efficacy of the novel \u201clateral approach\u201d combined with an enamel matrix derivative (EMD) and bone grafting in the regenerative surgical treatment of intrabony defects associated with an edentulous ridge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The innovative flap, called the \u201clateral approach,\u201d is explicitly designed for regeneration of unchallenged isolated intrabony defects associated with <jats:italic>edentulous<\/jats:italic> alveolar ridges. The flap is defined by a curved vertical incision on the buccal side opposite the treated defect and a sulcular incision on the buccal and defect\u2010associated sides, promoting uneventful healing and regeneration while minimizing complications.<\/jats:p><jats:p>Seven intrabony defects (one per patient) distal to the lower second molar were treated using the \u201clateral approach\u201d combined with EMD and grafting with deproteinized bovine bone mineral. The primary outcome was clinical attachment level (CAL) change. As additional parameters, pocket probing depth (PPD) reduction and complication rate were analyzed. All the outcomes were assessed 6 months post\u2010surgery and compared with the baseline values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Primary wound healing occurred in 100% of cases, and no complications were reported. At the 6\u2010month re\u2010evaluation, the initial median CAL of 6\u2009mm (interquartile range 5\u20138\u2009mm) was reduced to 3\u2009mm (3\u20135\u2009mm). The corresponding median PPD was reduced from 6\u2009mm (IQR 6\u20138\u2009mm) to 4\u2009mm (IQR 3\u20135\u2009mm). These differences were statistically significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The \u201clateral approach\u201d is a technique for the surgical treatment of intrabony defects associated with the edentulous ridge. Within the limitations of the study, this method seems to be suitable for distal intrabony defects in the lower second molars, which frequently develop after third molar extraction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70094","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:29:12Z","timestamp":1741771752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lateral Approach for Regenerative Treatment of Intrabony Defects Associated With an Edentulous Alveolar Ridge: A Prospective Case Series"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-3198","authenticated-orcid":false,"given":"Filip","family":"Hrom\u010d\u00edk","sequence":"first","affiliation":[{"name":"Clinic of Stomatology, St. Anne's University Hospital, Faculty of Medicine Masaryk University  Brno Czechia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad\u00e9la","family":"Haluskov\u00e1","sequence":"additional","affiliation":[{"name":"Clinic of Stomatology, St. Anne's University Hospital, Faculty of Medicine Masaryk University  Brno Czechia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydie Izakovi\u010dov\u00e1","family":"Holl\u00e1","sequence":"additional","affiliation":[{"name":"Clinic of Stomatology, St. Anne's University Hospital, Faculty of Medicine Masaryk University  Brno Czechia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_12_2_1","DOI":"10.11607\/prd.2584"},{"doi-asserted-by":"publisher","key":"e_1_2_12_3_1","DOI":"10.1111\/jcpe.13255"},{"doi-asserted-by":"publisher","key":"e_1_2_12_4_1","DOI":"10.1002\/JPER.19-0160"},{"doi-asserted-by":"publisher","key":"e_1_2_12_5_1","DOI":"10.1002\/JPER.17-0719"},{"issue":"2","key":"e_1_2_12_6_1","first-page":"136","article-title":"Guided Tissue Regeneration With Different Materials","volume":"10","author":"Cortellini P.","year":"1990","journal-title":"International Journal of Periodontics & Restorative Dentistry"},{"doi-asserted-by":"publisher","key":"e_1_2_12_7_1","DOI":"10.1111\/j.1600-051X.2011.01705.x"},{"doi-asserted-by":"publisher","key":"e_1_2_12_8_1","DOI":"10.1111\/prd.12048"},{"doi-asserted-by":"publisher","key":"e_1_2_12_9_1","DOI":"10.1111\/prd.12156"},{"doi-asserted-by":"crossref","unstructured":"Hrom\u010d\u00edk F. andA.Haluskov\u00e1. 2023. \u201cLateral Approach for the Regenerative Treatment of Intrabony Defects Associated With Edentulous Spaces. A Pilot Case.\u201d Poster session presented at the International Symposium on Soft Tissue Management around Teeth and Implants Florence Italy May 26\u201327.https:\/\/www.researchgate.net\/publication\/370465469_Lateral_approach_for_the_regenerative_treatment_of_intrabony_defects_associated_with_edentulous_spaces_A_pilot_case.","key":"e_1_2_12_10_1","DOI":"10.21203\/rs.3.rs-4425258\/v1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_11_1","DOI":"10.3390\/membranes12020219"},{"doi-asserted-by":"publisher","key":"e_1_2_12_12_1","DOI":"10.1111\/j.1600-0765.1996.tb00478.x"},{"doi-asserted-by":"publisher","key":"e_1_2_12_13_1","DOI":"10.1111\/prd.12504"},{"doi-asserted-by":"publisher","key":"e_1_2_12_14_1","DOI":"10.1034\/j.1600-051X.2002.291105.x"},{"doi-asserted-by":"publisher","key":"e_1_2_12_15_1","DOI":"10.1111\/j.1600-051X.1991.tb01117.x"},{"issue":"3","key":"e_1_2_12_16_1","first-page":"180","article-title":"Long\u2010Term Outcomes of Periodontal Regenerative Procedures for the Treatment of Intrabony Periodontal Defects: A Systematic Review and Meta\u2010Analysis","volume":"23","author":"Kyung N.","year":"2021","journal-title":"Journal of International Academy of Periodontology"},{"doi-asserted-by":"publisher","key":"e_1_2_12_17_1","DOI":"10.1902\/jop.2001.72.4.512"},{"doi-asserted-by":"publisher","key":"e_1_2_12_18_1","DOI":"10.1097\/JS9.0000000000000940"},{"doi-asserted-by":"publisher","key":"e_1_2_12_19_1","DOI":"10.1111\/j.1600-051X.2008.01245.x"},{"doi-asserted-by":"publisher","key":"e_1_2_12_20_1","DOI":"10.1111\/jcpe.13237"},{"doi-asserted-by":"publisher","key":"e_1_2_12_21_1","DOI":"10.1111\/jcpe.13381"},{"doi-asserted-by":"publisher","key":"e_1_2_12_22_1","DOI":"10.1002\/JPER.18-0415"},{"doi-asserted-by":"publisher","key":"e_1_2_12_23_1","DOI":"10.1111\/jcpe.13086"},{"doi-asserted-by":"publisher","key":"e_1_2_12_24_1","DOI":"10.1111\/j.1600-051X.1996.tb00534.x"},{"doi-asserted-by":"publisher","key":"e_1_2_12_25_1","DOI":"10.1111\/prd.12081"},{"doi-asserted-by":"publisher","key":"e_1_2_12_26_1","DOI":"10.1902\/jop.2004.75.5.726"},{"doi-asserted-by":"publisher","key":"e_1_2_12_27_1","DOI":"10.1111\/jcpe.12409"},{"doi-asserted-by":"publisher","key":"e_1_2_12_28_1","DOI":"10.26650\/eor.2022992668"},{"doi-asserted-by":"publisher","key":"e_1_2_12_29_1","DOI":"10.1016\/j.cden.2021.09.002"},{"doi-asserted-by":"publisher","key":"e_1_2_12_30_1","DOI":"10.1902\/jop.2010.100113"},{"doi-asserted-by":"publisher","key":"e_1_2_12_31_1","DOI":"10.1007\/s00784-021-04155-5"},{"doi-asserted-by":"publisher","key":"e_1_2_12_32_1","DOI":"10.1016\/j.identj.2022.09.001"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:56:32Z","timestamp":1748843792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/cre2.70094"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70094","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"type":"print","value":"2057-4347"},{"type":"electronic","value":"2057-4347"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70094"}}