{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T18:57:54Z","timestamp":1775329074998,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oral lichen planus (OLP) is an autoimmune disease with unknown etiology. Many OLP patients complain of xerostomia, and studies are still ongoing to find the reason for this manifestation. Aquaporin 5 has been expressed in salivary glands, and its physiological significance in transferring water as transcellular is properly identified. In this study, for the first time, we have investigated the serum and salivary levels of aquaporin 5 (as a salivary gland biomarker) in oral lichen planus patients with xerostomia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Thirty patients with OLP and xerostomia and 30 healthy individuals were chosen. The flow of stimulatory and non\u2010stimulatory saliva was calculated, and the serums, in addition to salivary levels of aquaporin 5, were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The level of Aquaporin 5 in serum and its output in stimulatory, and non\u2010stimulatory saliva were significantly decreased, the stimulatory and non\u2010stimulatory saliva flow was reduced, and the degree of xerostomia was significantly higher in the OLP group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aquaporin 5 is implicated in OLP patients in several ways such as impaired salivary functioning, xerostomia or dry mouth, diminished repair ability of the mucosal lesion, increased apoptosis, and probable carcinogenesis in this premalignant lesion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70107","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T16:38:43Z","timestamp":1742315923000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Decreased Serum and Salivary Levels of Aquaporin 5 in Oral Lichen Planus"],"prefix":"10.1002","volume":"11","author":[{"given":"Farzaneh","family":"Agha\u2010Hosseini","sequence":"first","affiliation":[{"name":"Dental Research Center, Dentistry Research Institute Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Oral Medicine, Faculty of Dentistry Tehran University of Medical Sciences Tehran Iran"},{"name":"The Academy of Medical Sciences Tehran  Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalda","family":"Elham","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dentistry Tehran University of Medical 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