{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:53:33Z","timestamp":1785880413064,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Late\u2010stage secondary alveolar bone grafting (SBG) has a poor prognosis; however, the case selection and timing of orthodontic treatment have not been thoroughly investigated. This study aimed to clarify the prognosis of early\u2010SBG and late\u2010SBG in patients with unilateral or bilateral cleft lip and palate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fifty\u2010six patients underwent early\u2010SBG performed before the eruption of the cleft\u2010adjacent lateral incisors or canines (early\u2010SBG group). Ten patients underwent late\u2010SBG requiring significant tooth movement for gap closure; SBG was performed before phase II treatment for treatment efficiency, and tooth movement began approximately 3 months post\u2010SBG (late\u2010SBG group). Pre\u2010SBG cleft width was measured; bone\u2010bridge formation using the Chelsea scale and cleft gap closure post\u2010SBG were evaluated. Types A and C bone bridges were considered adequate. These items were statistically compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cleft width in the early\u2010SBG group was significantly smaller than that in the late\u2010SBG group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There were no significant differences in the percentage of adequate bone\u2010bridge formation (<jats:italic>p<\/jats:italic>\u2009=\u20090.055) and cleft\u2010gap closure (<jats:italic>p<\/jats:italic>\u2009=\u20091.000) between groups. However, the ratio of type A bone bridges was significantly higher in the early\u2010SBG group than in the late\u2010SBG group (<jats:italic>p<\/jats:italic>\u2009=\u20090.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that, even in late\u2010SBG, early orthodontic tooth movement to the graft bone leads to the formation of an adequate bone bridge, similar to early\u2010SBG. However, the maintenance of cervical grafted bone after late\u2010SBG may be less than that after early\u2010SBG.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70116","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T16:39:32Z","timestamp":1742315972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Bone Formation After Early and Late Secondary Alveolar Bone Grafting in Patients With Unilateral and Bilateral Cleft Lip and Palate"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-7395","authenticated-orcid":false,"given":"Aya","family":"Maeda\u2010Iino","sequence":"first","affiliation":[{"name":"Field of Developmental Medicine, Health Research Course, Department of Orthodontics and Dentofacial Orthopedics Graduate School of Medical and Dental Sciences, Kagoshima University Kagoshima 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