{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:37:40Z","timestamp":1792179460392,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to evaluate the effectiveness of recombinant human bone morphogenetic protein\u20102 (rhBMP\u20102) coated biphasic calcium phosphate (BCP) in socket preservation in comparison to BCP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Patients who underwent extraction of maxillary premolars were randomized to receive rhBMP\u20102\/BCP (<jats:italic>n<\/jats:italic>\u2009=\u200915) and BCP alone (<jats:italic>n<\/jats:italic>\u2009=\u200915). All sites were primarily closed using a pedicled connective tissue flap. Biopsy was carried out in patients at 3 (<jats:italic>n<\/jats:italic>\u2009=\u200910), 6 (<jats:italic>n<\/jats:italic>\u2009=\u200910), and 9 (<jats:italic>n<\/jats:italic>\u2009=\u200910) months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 3 months, BMP and non\u2010BMP groups had 3.17% and 3.12% new bone formation, respectively, and 3.8% and 37.85% of residual grafts, respectively, and 25.86% and 25.99% connective tissue component, respectively. At 6 months, both groups revealed 67.42% and 16.55% essential bone growth, 1.74% and 3.04% of residual graft, and 1.3% and 67% connective tissue component, respectively. At 9 months, the BMP group revealed 93.6% new bone formation, 0.68% residual graft, and 1.9% connective tissue component, while the non\u2010BMP groups had 23.35% new bone formation, 4.45% residual graft, and 44.06% connective tissue component.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that rhBMP\u20102 coated BCP significantly enhanced early graft substitution in socket preservation sites compared to BCP alone. There was a significantly higher percentage of new bone formation in the rhBMP\u20102\/BCP group both at 6 and 9 months. Additionally, the rhBMP\u20102\/BCP group exhibited faster resorption of the graft material and earlier maturation of newly formed bone. These findings strongly suggest that rhBMP\u20102\/BCP can be an effective treatment modality for socket preservation, promoting predictable and accelerated bone regeneration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70134","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:16:36Z","timestamp":1747667796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effectiveness of Recombinant Human Bone Morphogenetic Protein\u20102 in Socket Preservation: A Randomized Controlled Clinical and Sequential Human Histological Trial (BMP\u20102 TRIAL)"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1391-6125","authenticated-orcid":false,"given":"Saravanan Sampoornam Pape","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Periodontology Army Dental Centre (Research &amp; Referral)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3355-1322","authenticated-orcid":false,"given":"Delfin Lovelina","family":"Francis","sequence":"additional","affiliation":[{"name":"Saveetha Dental College &amp; Hospitals Saveetha University, Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1373-968X","authenticated-orcid":false,"given":"Harshini","family":"Thirumoorthi","sequence":"additional","affiliation":[{"name":"Arunai Medical College &amp; Hospital Tiruvannamalai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4157-2864","authenticated-orcid":false,"family":"Rahul","sequence":"additional","affiliation":[{"name":"Department of Periodontology Army Dental Centre (Research &amp; Referral)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7689-2506","authenticated-orcid":false,"given":"Manish","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Periodontology Army Dental Centre (Research &amp; Referral)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9562-8032","authenticated-orcid":false,"given":"Harjeet","family":"Singh","sequence":"additional","affiliation":[{"name":"3 Corps Dental Unit, Army Dental Corps Indian Army  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7172-0369","authenticated-orcid":false,"given":"Shaswata","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Department of Periodontology Manipal College of Dental Sciences, Manipal Academy of Higher Education Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4708-8209","authenticated-orcid":false,"given":"Shaili","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Department of Periodontology &amp; Oral Implantology Kathmandu Medical College Public Limited Kathmandu Bagmati Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010176.pub3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13057"},{"issue":"8","key":"e_1_2_12_4_1","first-page":"613","article-title":"Grafting of the Maxillary Sinus Floor With Autogenous Marrow and Bone","volume":"38","author":"Boyne P. J.","year":"1980","journal-title":"Journal of Oral Surgery (American Dental Association: 1965)"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04248-1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34241"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2011.04.023"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513518561"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130207"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12156"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-021-00328-0"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/926291"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13423"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050337"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03735-y"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515594573"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0348"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5959"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12414"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.01.001"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-019-6340-9"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600114"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0b013e318287f2e2"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3171\/2021.3.FOCUS2171"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120339"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.2186\/jpr.JPR_D_20_00226"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002347"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.4.470"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001126"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-023-00491-1"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-023-00491-1"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12921"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140697"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e31829262a8"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.1999.260610.x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.09.008"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.01.042"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10167"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-020-0073-y"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T06:15:26Z","timestamp":1751004926000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/cre2.70134"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70134","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2024-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70134"}}