{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:21:54Z","timestamp":1793305314625,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The number of dental implants is constantly on the rise, and inflammation of their surrounding tissues is an increasing problem. In this randomized controlled trial, we investigated the effects of antibacterial dual\u2010light photodynamic therapy (aPDT) in peri\u2010implant disease in reduction of inflammation in the peri\u2010implant tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Forty patients with newly diagnosed peri\u2010implant disease were recruited. The diagnoses were established clinically and by radiological bone loss (RBL). Dual\u2010light aPDT was provided by indocyanine green mouth rinsing and 50:50, 405\u2009nm, and 810\u2009nm light applicator. The treatment group (<jats:italic>n<\/jats:italic>\u2009=\u200920) was randomized to use aPDT treatment at home for 4 weeks. The treatment was carried out once daily for 2 weeks, then twice daily for the next 2 weeks. The control group (<jats:italic>n<\/jats:italic>\u2009=\u200920) continued enhanced self\u2010care during the study period. Traditional measurement methods around the implant were measured at the beginning, at 2 weeks and at 4 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, VPI decreased in both groups. In the treatment group BOP decreased from mean (SD) 4.7\u2009\u00b1\u20091.3 to 1.8\u2009\u00b1\u20091.6, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001, but no change was observed in the control group (3.5\u2009\u00b1\u20092.3 to 3.0\u2009\u00b1\u20092.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.39). In the aPDT treatment group aMMP\u20108 decreased from mean (SD) 100\u2009\u00b1\u200941 to 72\u2009\u00b1\u200938, <jats:italic>p<\/jats:italic>\u2009=\u20090.027, but not in the control group (86\u2009\u00b1\u200954 to 86\u2009\u00b1\u200960, <jats:italic>p<\/jats:italic>\u2009=\u20090.38).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Regularly applied dual\u2010light aPDT reduces inflammation in the dental implant adjacent tissues. Dual\u2010light aPDT approach holds promise as an effective home care tool for implant patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70146","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T13:07:04Z","timestamp":1747660024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Peri\u2010Implant Diseases: Enhanced Antibacterial Photodynamic Therapy"],"prefix":"10.1002","volume":"11","author":[{"given":"Hanna","family":"La\u0308hteenma\u0308ki","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommi","family":"Pa\u0308tila\u0308","sequence":"additional","affiliation":[{"name":"Department of Pediatric Heart Surgery and Organ Transplantation, New Children's Hospital Helsinki University Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-5299","authenticated-orcid":false,"given":"Ismo T.","family":"Ra\u0308isa\u0308nen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rauni","family":"Kalliala","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland"},{"name":"Division of Periodontology, Department of Dental Medicine Karolinska Institutet Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/2176-9451.19.4.027-029.ebo"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2015.3955"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2441-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13585"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.18433\/jpps32084"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13823"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom7040079"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600803"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","unstructured":"L\u00e4hteenm\u00e4ki H.2022.Modern and Future aMMP\u20108 Point\u2010of\u2010Care\/Chairside Diagnostic and Treatment Modalities in Periodontitis and Peri\u2010Implantitis. University of Helsinki.","DOI":"10.1080\/14728222.2023.2240014"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/CIMB44030085"},{"issue":"3","key":"e_1_2_10_13_1","first-page":"297","article-title":"Methylene Blue in Place of Acridine Orange as a Photosensitizer in Photodynamic Therapy of Osteosarcoma","volume":"22","author":"Matsubara T.","year":"2008","journal-title":"In Vivo (Athens, Greece)"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232775"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj9050052"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10101240"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060494"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj10110206"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1632-2"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12956"},{"key":"e_1_2_10_21_1","first-page":"133","volume-title":"Effectiveness of Photodynamic Therapy in the Treatment of Periodontal and Peri\u2010Implant Diseases","author":"Sculean A.","year":"2020"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.69"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T06:15:07Z","timestamp":1751004907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/cre2.70146"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70146","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2024-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70146"}}