{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:51:00Z","timestamp":1780491060936,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess how chronotherapy influences recovery after bilateral third molar extraction when Dexketoprofen is administered as an anti\u2010inflammatory agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>A randomized cross\u2010over controlled trial with 10 patients with bilateral impacted third molar extraction was enrolled. For 7 days after the surgery, the chronotherapy group was prescribed one dose of Dexketoprofen (25\u2009mg) limited to daytime, while the control group were given two doses per day (every 12\u2009h). Pain intensity was recorded at baseline, 24, 48, and 72\u2009h, while facial swelling parameters were evaluated at baseline, 24, 72, and 168\u2009h (Day 7) postoperatively. Also, the inflammatory profile was analyzed for each patient by blood samples at baseline, 72 and 168\u2009h. The concentrations of IL\u20101\u03b2, IL\u20101a, IL\u20102, IL\u20104, IL\u20106, IL\u20107, IL\u201010, and IL\u201013 were measured using high\u2010sensitivity multiplex map human immunoassays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant differences in postoperative VAS pain, swelling, and mouth opening (trismus) measures were observed between the two groups. However, the chronotherapy group had reduced overall postoperative complications compared to the control group. Regarding postoperative recovery, pain intensity scores in the chronotherapy group at 24, 48, and 72\u2009h indicated a faster recovery than the control group. Blood samples analysis showed no statistical differences between the different inflammatory markers studied at 72\u2009h or Day 7 in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Daytime administration of NSAIDs might be sufficient to manage postoperative pain after third molar extraction, and complications were similar between both groups.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial Registration:<\/jats:bold>\n                      clinicaltrials. gov, Identifier database: NCT05176158.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70163","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T11:00:13Z","timestamp":1767956413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dexketoprofen Time\u2010Dependent Administration After Third Molar Extraction: A Pilot Randomized Cross\u2010Over Controlled Trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-8700","authenticated-orcid":false,"given":"Fabi\u00e1n","family":"P\u00e9rez\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Department of Dental Clinical Specialties University Complutense of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0955-0055","authenticated-orcid":false,"given":"Mohammad","family":"Abusamak","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Dalhousie Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire Virto","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Dental Clinical Specialties University Complutense of Madrid Madrid Spain"},{"name":"Department of Anatomy and Embriology, Faculty of Optics and Optometry University Complutense of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Miguel","family":"S\u00e1ez\u2010Alcaide","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Dental Clinical Specialties University Complutense of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haider","family":"Al\u2010Waeli","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Dalhousie Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faleh","family":"Tamimi","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Qatar University Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus Torres","family":"Garc\u00eda\u2010Denche","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Dental Clinical Specialties University Complutense of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.35234"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2023.2200495"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.05.036"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57215-y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(83)90227-X"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016359709091944"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-024-01539-4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2023.08.001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/1119-3077.113450"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246625"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140700"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4378"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2022.04.001"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2006.100271"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2001.118863"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201801452"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-011-0295-3"},{"issue":"1","key":"e_1_2_11_19_1","first-page":"9","article-title":"Accuracy of Pederson and Modified Parant Scale for Predicting Difficulty Level of Mandibular Third Molars","volume":"8","author":"Janjua O. 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