{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T12:30:30Z","timestamp":1781353830876,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To verify that osseointegration maturation under immediate restoration is correlative with active release of cytokines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>The participants needing the restoration of a single missing mandibular molar were randomized into immediate restoration (IR) and conventional restoration group (CR). All eligible patients were recalled for collecting peri\u2010implant crevicular fluid (PICF) samples according to the scheduled follow\u2010up time point during osseointegration and functional loading. Detection of receptor activator of nuclear factor\u2010KB ligand, osteoprotegerin, and cathepsin K in PICF was conducted to statistically analyze their difference between IR and CR groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the osseointegration period, the overall level of these cytokines in the IR group was statistically higher than that of the corresponding cytokine in the CR group. During functional loading, the overall level of the each cytokine in CR was statistically different from that of the corresponding cytokine during osseointegration, but the overall level of each cytokine was not statistically different between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The rapid osseointegration maturation under immediate restoration is probably correlative with active release of cytokines related with bone metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70193","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T11:32:43Z","timestamp":1754998363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["RANKL, OPG, and CTS\u2010K Release in Bone Response to Immediate Nonfunctional Loading of a Single Implant in Mandibular Molar Sites During Osseointegration Establishment"],"prefix":"10.1002","volume":"11","author":[{"given":"Xiaowen","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Dental Implant Affiliated Stomatological Hospital of Sun Yat\u2010sen University, Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3721-9125","authenticated-orcid":false,"given":"Yijie","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Dental Implant Affiliated Stomatological Hospital of Sun Yat\u2010sen University, Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuexia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dental Implant Affiliated Stomatological Hospital of Sun Yat\u2010sen University, Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04154-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2005.04.015"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crimmu.2024.100080"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14194030"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.09.006"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/173573"},{"issue":"5","key":"e_1_2_11_9_1","first-page":"668","article-title":"Removal Torque and Histomorphometric Investigation of 4 Different Titanium Surfaces: An Experimental Study in the Rabbit Tibia","volume":"15","author":"Cordioli G.","year":"2000","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12354"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12900"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.10197"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11080835"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2021.104347"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14051036"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080648"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043603"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-014-4657-7"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0276269"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12635"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2019.104509"},{"issue":"2","key":"e_1_2_11_22_1","first-page":"99","article-title":"Histologic and Histomorphometric Evaluation of the Bone Response Around a Hydroxyapatite\u2010Coated Implant Retrieved After 15 Years","volume":"29","author":"Iezzi G.","year":"2009","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"issue":"1","key":"e_1_2_11_23_1","first-page":"54","article-title":"Immediately Loaded Screw Implant Retrieved After a 12\u2010year Loading Period: A Histologic and Histomorphometric Case Report","volume":"1","author":"Iezzi G.","year":"2009","journal-title":"Journal of Osseointegration"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-024-01228-z"},{"issue":"1","key":"e_1_2_11_25_1","first-page":"1","article-title":"The Effect of RANKL\/OPG Balance on Reducing Implant Complications","volume":"8","author":"Kapasa E. 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