{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:28:51Z","timestamp":1787318931414,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This case series aimed to evaluate the healing potential of apical tissues with large periapical radiolucencies (&gt;\u200910\u2009mm) after apical microsurgery with L\u2010PRF. The secondary objectives were to evaluate L\u2010PRF's benefits and adverse effects as well as to aid in the development of a clinical protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This case series was conducted in accordance with the Preferred Reporting Items for Case Reports in Endodontics (PRICE) 2020 guidelines. Thirteen patients with persistent endodontic infections, unresponsive to nonsurgical root canal treatment\/retreatment, were treated at the Restorative and Oral Surgery Departments with endodontic microsurgery. L\u2010PRF preparation followed Choukroun et al. (2001) and the L\u2010PRF 2018 guidelines under the supervision of an experienced consultant. Postoperative follow\u2010up included a phone call at 24\u2009h to assess pain, swelling, and daily functions. Sutures were removed at 7 days, and a 6\u2010month clinical and radiographic review was conducted. The clinical assessment included patient\u2010reported symptoms and extraoral and intraoral examinations. Periapical radiographs were assessed for periapical healing based on Rud et al.'s (1972) radiographic criteria. Radiographs were reviewed by one clinician under standardized conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Histopathological analyses identified 76.9% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) radicular cysts and 23.0% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093) periapical granulomas from the 13 cases. At the 6\u2010month review, 76.9% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) showed incomplete healing, 15.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) demonstrated complete healing, and 7.7% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091) had incomplete healing at 4 months. All patients remained asymptomatic with no reported complaints. Radiographic assessments showed a significant reduction in the size of periapical radiolucency in all cases. At 24\u2009h, 69.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099) reported no pain, while mild pain was noted in 15.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092). Swelling was observed in 69.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099) and absent in 15.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), with missing records for 15.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>L\u2010PRF appears beneficial in endodontic microsurgery. However, larger, low\u2010bias studies with extended follow\u2010up periods are needed for definitive conclusions on its application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70198","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T05:51:08Z","timestamp":1765864268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Will L\u2010PRF Be the Future of Endodontic Microsurgery? A Series of Case Reports"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-9075","authenticated-orcid":false,"given":"Natrah Ahmad","family":"Fuad","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dentistry University of Malaya Kuala Lumpur Malaysia"},{"name":"Department of Restorative Dentistry Edinburgh Dental Institute Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Pitros","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Edinburgh Dental Institute Edinburgh UK"},{"name":"Private Practice limited to Oral Surgery Cyprus Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Brown","sequence":"additional","affiliation":[{"name":"Specialty Registrar in Orthodontics (StR), Manchester Dental Hospital Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Besi","sequence":"additional","affiliation":[{"name":"Barts and The London School of Medicine and Dentistry London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gien.2015.08.003"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.06.023"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.11.023"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-023-01204-z"},{"key":"e_1_2_14_6_1","first-page":"55","article-title":"A: Une Opportunite\u0301 en Paro\u2010Implantologie: Le PRF","volume":"42","author":"Choukroun J.","year":"2001","journal-title":"Implantodontie"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.011"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12702"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.10.007"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.04.004"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.32098\/mltj.01.2014.02"},{"issue":"8","key":"e_1_2_14_12_1","first-page":"51","article-title":"Efficacy of Healing Process of Bone Defects After Apicectomy: Results After 6 and 12 Months","volume":"60","author":"Dominiak M.","year":"2009","journal-title":"Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.02.022"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005511.pub3"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdr.ijdr_810_22"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(07)80131-2"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-060116-022805"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.12.012"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13440"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2016.1226497"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2343-z"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03309-1"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13285"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01099.x"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13750"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01873.x"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01323.x"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13098"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2008.01538.x"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/2278-9626.163341"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1995.tb00155.x"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2001.00369.x"},{"key":"e_1_2_14_33_1","unstructured":"Pinto N. 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