{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:42:52Z","timestamp":1769838172541,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Due to ozonated water's antimicrobial and anti\u2010inflammatory properties, it may be used as a supplementary treatment to scaling and root planing (SRP). The present study aimed to evaluate the clinical effectiveness of using ozonated water instead of tap water during the SRP for people with chronic generalized periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>This randomized clinical trial was conducted on 30 patients with generalized periodontitis Stages I and II, randomly allocated to two groups. Test sites were subjected to ozonated water, and control sites were subjected to tap water. The clinical periodontal parameters were measured at baseline, the 4th, and 8th week of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Findings showed a significant decrease in periodontal pocket depth (PPD), clinical attachment level (CAL), and gingival index (GI) at both the 4th and the 8th week of treatment in both groups. PPD was further reduced in the test group, but the difference between the two groups was not significant. However, the greater reduction of CAL at the 4th and 8th week (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively) and also the greater reduction of GI at the 4th week (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) was observed in the test group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both the test and control groups showed clinical improvement following nonsurgical periodontal therapy. The ozonated water group demonstrated significantly greater reductions in CAL at the 4th and 8th weeks, and in GI at the 4th week. However, the magnitude of these differences was modest and may have limited clinical relevance. Further research is needed to confirm long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70216","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T10:59:44Z","timestamp":1757329184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Ozonated Water in Nonsurgical Management of Periodontitis"],"prefix":"10.1002","volume":"11","author":[{"given":"Mohadese","family":"Yazdanpanahbahabadi","sequence":"first","affiliation":[{"name":"Department of Periodontology Babol University of Medical Sciences Babol Mazandran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojan","family":"Ghafouri","sequence":"additional","affiliation":[{"name":"Department of Periodontology Babol University of Medical Sciences Babol Mazandaran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Fereidooni","sequence":"additional","affiliation":[{"name":"Department of Periodontology Babol University of Medical Sciences Babol Mazandaran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Hosseinkazemi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Babol University of Medical Sciences Babol Mazandaran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12177"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01309.x"},{"key":"e_1_2_9_4_1","unstructured":"Canadian Agency for Drugs and Technologies in Health.2016. Dental Scaling and Root Planing for Periodontal Health: A Review of Clinical Effectiveness Cost\u2010effectiveness and Guidelines.https:\/\/www.cadth.ca\/sites\/default\/files\/pdf\/htis\/2016\/RC0813%20Scaling%20and%20Root%20Planing%20Final.pdf."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12935"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01185.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1990.0194"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0711-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2006.00390.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2015\/14464.6303"},{"issue":"5","key":"e_1_2_9_11_1","first-page":"79","article-title":"Effect of Ozonised Water on Chronic Periodontitis: A Clinical Study","volume":"5","author":"Katti S. 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