{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:11:15Z","timestamp":1760746275748,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Through a scoping review, this study meticulously mapped and characterized these nanostructured clays used to release antibacterial active compounds from direct restorative dental materials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The systematic approach involved searches in the PubMed\/MEDLINE, Lilacs, Web of Science, Scopus, ScienceDirect, and Embase databases. Two independent and calibrated researchers (kappa: 0.94) performed all systematic steps according to the PRISMA guideline and the Joanna Briggs Institute Scoping Review Methodology Group (JBI) protocol. The reviewers developed a data extraction table to gather key information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 782 articles were retrieved in the initial search using the specified strategies. After thoroughly reviewing the manuscripts, five were selected following the exclusion of duplicates and application of eligibility criteria. Montmorillonite and halloysite nanotubes emerged as the predominant nanostructured clay. Cetylpyridinium chloride was the most common active agent, notable for its antibacterial properties. Resin\u2010based composites were the most frequently studied direct restorative material for the prevention of recurrent caries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the number of primary studies published in the literature was limited, montmorillonite and halloysite nanotubes appear to be promising nanocarriers for antibacterial active compounds in direct restorative dental materials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.70219","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T11:05:31Z","timestamp":1757329531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanostructured Clays Used as Carriers for Controlled Delivery of Antibacterial Compounds From Direct Restorative Dental Materials: A Scoping Review"],"prefix":"10.1002","volume":"11","author":[{"given":"B\u00e1rbara Faria Sa","family":"de Barbosa","sequence":"first","affiliation":[{"name":"Department of Dentistry Universidade Federal do Rio Grande do Norte (UFRN) Natal Rio Grande do Norte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Le\u00f4ncio","family":"Ferreira Neto","sequence":"additional","affiliation":[{"name":"Department of Dentistry Universidade Federal do Rio Grande do Norte (UFRN) Natal Rio Grande do Norte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca Jennifer Duarte","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Dentistry Universidade Federal do Rio Grande do Norte (UFRN) Natal Rio Grande do Norte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Sales Osterno","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Group of Chemistry of Advanced Materials (GQMat), Department of Analytical Chemistry and Physical Chemistry Universidade Federal do Cear\u00e1 (UFC) Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moan J\u00e9fter Fernandes","family":"Costa","sequence":"additional","affiliation":[{"name":"College of Dentistry Universidade de Pernambuco (UPE) Arcoverde Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9119-8435","authenticated-orcid":false,"given":"Pedro Henrique","family":"Sette\u2010de\u2010Souza","sequence":"additional","affiliation":[{"name":"College of Dentistry Universidade de Pernambuco (UPE) Arcoverde Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre Bas\u00edlio Almeida","family":"Fechine","sequence":"additional","affiliation":[{"name":"Group of Chemistry of Advanced Materials (GQMat), Department of Analytical Chemistry and Physical Chemistry Universidade Federal do Cear\u00e1 (UFC) Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8795-9967","authenticated-orcid":false,"given":"Victor Pinheiro","family":"Feitosa","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, College of Dentistry University of Iowa Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4313-5776","authenticated-orcid":false,"given":"Boniek Castillo Dutra","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Dentistry Universidade Federal do Rio Grande do Norte (UFRN) Natal Rio Grande do Norte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clay.2023.106946"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clay.2020.105953"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_194_19"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2020.103541"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2016.09.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2020.103675"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2019.03.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.2c01080"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbt.2015.07.005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557522666220330145130"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2021.1862792"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2021.103731"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-018-2908-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900332"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn507170s"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.7.2982-2992.2001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0tb01031f"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.05.068"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1056534"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00576-20"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.09.045"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201900055"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020544"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40005-016-0258-8"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.30"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2017.04.015"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.09.019"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-021-00629-w"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2012.12.014"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2023.12.003"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano13192690"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.4265\/BIO.25.45"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels7020059"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2021.10.009"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T06:13:42Z","timestamp":1760681622000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/cre2.70219"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70219","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"type":"print","value":"2057-4347"},{"type":"electronic","value":"2057-4347"}],"subject":[],"published":{"date-parts":[[2025,9,8]]},"assertion":[{"value":"2025-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70219"}}