{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:36:03Z","timestamp":1788820563508,"version":"build-2803163510"},"reference-count":93,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Periodontal disease (PD) and cognitive disorders (CDs) are common in older people, and these variables appear to be linked. The aim of this article was to assess this association using an umbrella meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed and MEDLINE were searched for records until June 2025. The groups were compared using odds ratio (OR) and relative risk (RR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 20 meta\u2010analyses were included. Individuals with PD and its consequences had higher chances of having\/developing all\u2010type CDs: periodontitis (OR\u2009=\u20091.65, 95% CI: 1.37\u20131.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090.0001), tooth loss (OR\u2009=\u20091.51, 95% CI: 1.32\u20131.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090.0001). The risk was much higher for patients with severe periodontitis: (OR\u2009=\u20092.69, 95% CI: 2.26\u20133.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090.0001). Pooled analysis for cohort studies was (RR\u2009=\u20091.26, 95% CI: 1.20\u20131.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PD is associated with CDs with low to moderate certainty of evidence measured by GRADE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70240","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T05:55:44Z","timestamp":1762926944000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Periodontitis and Tooth Loss Are Associated With Higher Risks of Cognitive Disorders: A Systematic Umbrella Meta\u2010Analysis"],"prefix":"10.1002","volume":"11","author":[{"given":"Balen Hamid","family":"Qadir","sequence":"first","affiliation":[{"name":"Department of Dentistry Komar University of Science and Technology Sulaymaniyah Kurdistan Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-9514","authenticated-orcid":false,"given":"Mohammed Khalid","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Paramedical Sciences, Aix\u2010Marseille University, French National Center of Scientific Research (CNRS), French Blood Establishment (EFS), Bio\u2010Cultural Anthropology, Law, Ethics and Health Laboratory (ADES) Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yad Mariwan Mohammed","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Dentistry Tishk International University Sulaymaniyah Kurdistan Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Handren Ameer","family":"Kurda","sequence":"additional","affiliation":[{"name":"College of Dentistry Sulaymaniyah University Sulaymaniyah Kurdistan Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6730-5114","authenticated-orcid":false,"given":"Tara Ali","family":"Rasheed","sequence":"additional","affiliation":[{"name":"College of Dentistry Sulaymaniyah University Sulaymaniyah Kurdistan Iraq"},{"name":"Department of Dentistry American University of Iraq, Sulaimani (AUIS) Sulaymaniyah Kurdistan Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Hama","family":"Noori","sequence":"additional","affiliation":[{"name":"Department of Psychotic Disorders Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zana Fuad","family":"Noori","sequence":"additional","affiliation":[{"name":"Department of Dentistry American University of Iraq, Sulaimani (AUIS) Sulaymaniyah 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