{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:14:05Z","timestamp":1779174845032,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Chronic kidney disease (CKD) is relatively common in patients with rheumatoid arthritis (RA). Periodontitis and periodontopathic\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      are risk factors for CKD. However, the association of serum immunity to\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      and its peptidylarginine deiminase (PPAD), as well as periodontitis severity, with CKD in relation to RA has not been elucidated. The present study evaluated whether or not serum immunoglobulin G (IgG) titers against\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      and PPAD and periodontitis severity are associated with CKD in patients with RA and periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Demographic, comorbidity, rheumatologic, and periodontal data were collected from 127 patients with RA and periodontitis in a retrospective cohort study. CKD was defined as an estimated glomerular filtration rate (eGFR)\u2009&lt;\u200960\u2009mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      and\/or proteinuria of \u2265\u20093 months\u2019 duration. Serum IgG titers against\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      and PPAD were determined using an electrochemiluminescence immunoassay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty patients showed an eGFR &lt;\u200960\u2009mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      , while no patients had proteinuria. The 20 CKD patients were significantly older (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), had higher percentages of former smokers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), had more sites with probing depth and clinical attachment level \u2265\u20094\u2009mm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and had higher levels of serum creatinine and eGFR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for both) and anti\u2010\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      IgG titers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) than the 107 non\u2010CKD patients. A significant association was observed between anti\u2010\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      IgG titers and eGFR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for both) by bivariate and multivariate analyses and between anti\u2010\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      IgG titers and CKD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) using a multiple logistic regression analysis after adjusting for age, gender, smoking status, comorbidity, RA condition, and RA\u2010related drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results suggest that serum IgG titers against\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      , but not against PPAD, are associated with CKD in patients with RA and periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70271","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:55:37Z","timestamp":1769694937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association Between Serum Immunoglobulin G Titers Against\n                    <i>Porphyromonas gingivalis<\/i>\n                    and Chronic Kidney Disease in Patients With Rheumatoid Arthritis and Periodontitis: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8250-4234","authenticated-orcid":false,"given":"Tetsuo","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Dentistry National Hospital Organization Niigata 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