{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:09:54Z","timestamp":1779174594319,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this systematic review and meta\u2010analysis was to evaluate the impact of open proximal contacts on peri\u2010implant tissue changes, specifically marginal bone levels, probing pocket depth, and the incidence of peri\u2010implant diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic databases were searched to identify non\u2010randomized observational studies comparing open and closed proximal contacts. Risk of bias was assessed using the Cochrane Collaboration's tool and data were analyzed with a statistical software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 276 studies initially identified, five met the inclusion criteria, involving 4882 dental implants. Meta\u2010analysis indicated that open proximal contacts were associated with greater, but not statistically significant, marginal bone changes (mean difference (MD) 0.07; 95% confidence interval (CI) \u22120.09 to 0.24;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.38); probing pocket depths (MD 0.11; 95% CI \u22120.29 to 0.51;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.59) and a higher incidence of peri\u2010implantitis (relative risk (RR) 1.63; 95% CI 0.88\u20133.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.12) compared to closed contacts. Open proximal contact was associated with a significant increase in incidence of peri\u2010implant mucositis (RR 1.74; 95% CI 1.06\u20132.86;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Open proximal contacts are associated with increased probing pocket depths and marginal bone changes and could be a risk indicator for peri\u2010implant mucositis. Further research is needed to assess long\u2010term effects and to develop preventive measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70278","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T21:15:51Z","timestamp":1769462151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Open Proximal Contacts on Peri\u2010Implant Diseases: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-9491","authenticated-orcid":false,"given":"Momen A.","family":"Atieh","sequence":"first","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAE"},{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago Dunedin New Zealand"},{"name":"School of Dentistry University of Jordan Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maanas","family":"Shah","sequence":"additional","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer","family":"Hakam","sequence":"additional","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaleifa","family":"Bohamedi","sequence":"additional","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Tawse\u2010Smith","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-3494","authenticated-orcid":false,"given":"Nabeel H. 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