{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:15:23Z","timestamp":1788279323712,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of spatial superimposition of cone\u2010beam computed tomography (CBCT) scans acquired at baseline and 6\u2010month follow\u2010up for monitoring bone healing in mandibular cystic lesions, aiming to reduce variability in conventional volumetric comparisons and enhance accuracy, reproducibility, and spatial fidelity of radiographic assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Two CBCT scans of a single patient (baseline, T0; follow\u2010up, T1) were imported into 3D Slicer v5.8.0. The mandible was isolated by manually cropping a region of interest, and the cystic lesion was segmented semi\u2010automatically using the Grow from Seeds tool. A rigid six\u2010degree\u2010of\u2010freedom registration aligned T1 to T0; the resulting transformation matrix was applied to the T1 segmentation to enable direct voxel\u2010wise comparison. Lesion volumes were measured, and spatial subtraction analysis quantified the resorbed area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lesion volume decreased from 1841.64\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      at T0 to 1362.62\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      at T1, corresponding to an absolute reduction of 479.02\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      (26.0%). The subtraction mask accurately localized regressed voxels, confirming both the magnitude and spatial distribution of bone healing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Potential limitations related to CBCT artifacts and the need for operator\u2010dependent manual steps should be considered when interpreting the results. Overall, CBCT superimposition with semi\u2010automatic segmentation provides an objective, consistent, and anatomically precise approach for monitoring mandibular cyst regression and may represent a useful tool to support conservative management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70292","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:11:36Z","timestamp":1771405896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CBCT Image Superimposition for Longitudinal Monitoring of Mandibular Cyst Healing: A Technical Note"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3756-3580","authenticated-orcid":false,"given":"Francesco","family":"Fanelli","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0198-6753","authenticated-orcid":false,"given":"Angela","family":"Tisci","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2153-0778","authenticated-orcid":false,"given":"Khrystyna","family":"Zhurakivska","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5647-4414","authenticated-orcid":false,"given":"Giuseppe","family":"Troiano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery LUM University Casamassima Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-05730-y"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2021.03.004"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.09.004"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-05167-9"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11282-020-00459-6"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16921-w"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.7150"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-05612-7"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2020.06.011"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/30642039"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13099"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.5624\/isd.20220130"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-06061-y"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01404-7"}],"container-title":["Clinical 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