{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:14:05Z","timestamp":1779174845068,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the effect of sodium dicholoroisocyanurate (NaDCC) as intracanal medicament on the dentin microhardness and fracture resistance of teeth compared to calcium hydroxide (CH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Root canals of mandibular premolars (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009153) were instrumented and randomized into two treatment groups and an untreated control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200951). Treatment groups received either NaDCC or CH. After 1 week, 1 month, or 3 months, 17 teeth were randomly selected from each group, and two root cylinders were obtained: one for fracture resistance and the other for microhardness test. Two\u2010way ANOVA, one\u2010way ANOVA, and Tukey post hoc tests were used for statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The microhardness and fracture resistance in the control and CH groups were not affected by time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, NaDCC caused significant decreases in dentin microhardness after 1 month and 3 months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) as well as in fracture resistance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) after 1 month. The groups comparison at each time point showed no significant differences in microhardness and fracture resistance after 1 week (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, after 1 month, a significant reduction in microhardness and fracture resistance was detected for NaDCC and in the fracture resistance for CH (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). After 3 months, compared to the control group, lower microhardness in NaDCC and CH groups and lower fracture resistance in CH group were detected (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Short\u2010term application of NaDCC and CH did not adversely affect dentin microhardness. However, prolonged use reduced dentin microhardness, and both medicaments significantly decreased fracture resistance compared with the control group. Limiting the duration of intracanal medicament application is therefore recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70294","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:23:27Z","timestamp":1770150207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of Sodium Dichloroisocyanurate and Calcium Hydroxide as Intracanal Medicaments on Microhardness and Fracture Resistance of Dentin: An In Vitro Study"],"prefix":"10.1002","volume":"12","author":[{"given":"Fereshte","family":"Sobhnamayan","sequence":"first","affiliation":[{"name":"Department of Endodontics, School of Dentistry Shiraz University of Medical Science Shiraz Fars Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Adl","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Biomaterial Research Center, School of Dentistry Shiraz University of Medical Science Shiraz Fars Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9625-7625","authenticated-orcid":false,"given":"Negin","family":"Firouzi","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry Shiraz University of Medical Science Shiraz Fars Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Moravej","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry Shiraz University of Medical Science Shiraz Fars Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samina","family":"Gavahianjahromi","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry Shiraz University of Medical Science Shiraz Fars Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","first-page":"123","article-title":"The Ability of Triple Antibiotic Paste and Calcium Hydroxide in Disinfection of Dentinal Tubules","volume":"9","author":"Adl A.","year":"2014","journal-title":"Iranian Endodontic Journal"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12575"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12798"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2002.00097.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1979.tb02582.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.05.011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2005.11.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.21608\/adjc.2024.246279.1421"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2007.00541.x"},{"issue":"2","key":"e_1_2_10_11_1","first-page":"134","article-title":"Comparative Evaluation of Calcium Hydroxide and Other Intracanal Medicaments on Postoperative Pain in Patients Undergoing Endodontic Treatment: A Systematic Review and Meta\u2010Analysis","volume":"26","author":"Hegde V. R.","year":"2023","journal-title":"Journal of conservative dentistry: JCD"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200104000-00009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCDE.JCDE_99_25"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.09.018"},{"key":"e_1_2_10_15_1","unstructured":"Kuechler T.(1999). Using an Equilibrium Model to Predict Bioeidal Efficacy (CT) for NaDCC and TCCA.Report No: S\u20109906 May 10 1999."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1206"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.06.002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2025.07.015"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13731"},{"issue":"2","key":"e_1_2_10_20_1","first-page":"110","article-title":"Effect of Different Irrigation Protocols and Calcium Hydroxide Dressing on the Microhardness of Root Canal Dentin","volume":"34","author":"Pinto L.","year":"2020","journal-title":"Giornale Italiano Di Endodonzia"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01911.x"},{"key":"e_1_2_10_22_1","first-page":"1266","article-title":"Use of Calcium Hydroxide Between Visits in Endodontic Treatment","author":"Silva W. 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