{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:15:37Z","timestamp":1788279337155,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370986"],"award-info":[{"award-number":["82370986"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Effective management of post\u2010endodontic pain is crucial for patient comfort. Although ketorolac is used for this purpose, its efficacy relative to other analgesics remains uncertain. This study systematically assesses evidence from randomized clinical trials that investigate the comparative effectiveness of ketorolac and other analgesic agents for the control of post\u2010endodontic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This study conducted a comprehensive search across several databases, including PubMed, Web of Science, ScienceDirect, Cochrane Library, Embase, Scopus, SinoMed, CNKI, Webvpn, and Wanfang Data. Search deadline was around August 2025. The study employed the inverse variance approach and a random effects model to analyze continuous data, utilizing the standardized mean as the comprehensive effect indicator. For dichotomous data, this study applied the risk ratio (RR), fixed\u2010effect analysis model, and Mantel\u2013Haenszel statistical methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our database search identified 386 potentially relevant studies. Ultimately, seven studies were selected for qualitative analysis, and five were chosen for quantitative analysis. The qualitative assessment indicated that five studies favored ketorolac, one study reported similar analgesic effects between ketorolac and alternative medications, while one study concluded that ketorolac was less effective. The quantitative analysis demonstrated a statistically significant difference in the analgesic effect of ketorolac compared to other drugs at 6\u2009h post\u2010administration. However, the analgesic effects of ketorolac did not show statistically significant differences compared to other medications at 12 or 24\u2009h post\u2010administration. Additionally, a lower proportion of patients required supplementary drug treatment after receiving ketorolac compared to those treated with other analgesics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta\u2010analysis concluded that ketorolac is effective for managing post\u2010endodontic pain within the first 6\u2009h and reduces the need for rescue medication compared to alternatives, thereby supporting its use as a favorable option following root canal treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70295","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:43:26Z","timestamp":1771400606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effectiveness of Ketorolac in Relieving Pain Associated With Root Canal Therapy: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0978-4456","authenticated-orcid":false,"given":"Ruijing","family":"Ping","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Kang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhen","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4792-1833","authenticated-orcid":false,"given":"Haozhen","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-328X","authenticated-orcid":false,"given":"Li\u2010an","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.a42654"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250883"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199223060-00003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/jpr.S280571"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2024-002719"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-1007-2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.50371"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.125162"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199753010-00012"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.05.014"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15241"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.b1044039"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.940635"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2009.05.022"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-05412-1"},{"issue":"12","key":"e_1_2_11_17_1","first-page":"921","article-title":"Ketorolac, an Injectable Nonnarcotic Analgesic","volume":"9","author":"Litvak K. M.","year":"1990","journal-title":"Clinical Pharmacy"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006294597"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01950.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.02.006"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0099-2399(96)80272-x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.12.012"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-023-04203-x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(92)90233-p"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0099-2399(06)81176-3"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19031399"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.57086"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-0707.144574"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.55388"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601812010340"},{"key":"e_1_2_11_31_1","first-page":"2","article-title":"SPRIX (Ketorolac Tromethamine) Nasal Spray: A Novel Nonopioid Alternative for Managing Moderate to Moderately Severe Dental Pain","volume":"33","author":"Snyder M. B.","year":"2012","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.09.011"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.138875"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2017.03.003"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.14422"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.12.010"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12198"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59101746"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cre2.70295","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:18:52Z","timestamp":1788275932000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/cre2.70295"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70295","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]},"assertion":[{"value":"2025-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70295"}}