{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:15:23Z","timestamp":1788279323739,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate, through a systematic review, the clinical effectiveness of platelet\u2010rich fibrin (PRF) in periodontal soft tissue repair compared with conventional regenerative techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This systematic review followed PRISMA 2020 guidelines and was registered in PROSPERO (CRD42024617061). Searches were conducted in PubMed, Scopus, Web of Science, ScienceDirect, and LILACS, complemented by gray literature sources. Randomized clinical trials evaluating PRF or its derivatives in periodontal soft tissue repair were included. From 996 identified records, 28 studies met the eligibility criteria and were included in the qualitative analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PRF demonstrated clinical outcomes comparable to conventional techniques such as connective tissue grafts and other biomaterials for root coverage and periodontal regeneration. In addition, PRF was associated with reduced surgical morbidity, lower postoperative discomfort, and shorter surgical time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PRF represents a promising autologous biomaterial for periodontal soft tissue repair, providing clinical outcomes similar to conventional grafting techniques with lower morbidity. Further well\u2010designed clinical trials with standardized protocols and long\u2010term follow\u2010up are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70327","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T07:59:28Z","timestamp":1777363168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of Platelet\u2010Rich Platelet Aggregates (PRFs) in Soft Tissue Repair in Periodontics: A Systematic Review"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-3129","authenticated-orcid":false,"given":"Ilan Hudson Gomes de","family":"Santana","sequence":"first","affiliation":[{"name":"Health Sciences Center, Undergraduate Student in Dentistry Federal University of Para\u00edba  Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozawa Brasil","family":"de J\u00fanior","sequence":"additional","affiliation":[{"name":"Health Sciences Center Federal University of Para\u00edba (UFPB)  Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson Jara","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Health Sciences Center, Undergraduate Student in Dentistry Federal University of Para\u00edba  Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia Caetana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Health Sciences Center Federal University of Para\u00edba (UFPB)  Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Marcos Pereira","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Health Sciences Center Federal University of Para\u00edba (UFPB)  Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick Andres Alpaca","family":"Zevallos","sequence":"additional","affiliation":[{"name":"Catholic University of Santa Mar\u00eda  Santa Mar\u00eda Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Ramiro Rojas","family":"Manrique","sequence":"additional","affiliation":[{"name":"Catholic University of Santa Mar\u00eda  Santa Mar\u00eda Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime S.","family":"Gallegos Zanabria","sequence":"additional","affiliation":[{"name":"Catholic University of Santa Mar\u00eda  Santa Mar\u00eda Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Coelho","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"S\u00e3o Leopoldo Mandic College  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ennyo Sobral Crispim","family":"da Silva","sequence":"additional","affiliation":[{"name":"Professor of Periodontics Federal University of Para\u00edba  Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"issue":"3","key":"e_1_2_11_3_1","article-title":"Advanced Platelet\u2010Rich Fibrin and Connective Tissue Graft for Treating Marginal Tissue Recessions: A Randomized, Controlled Split\u2010Mouth Study","volume":"15","author":"Abu\u2010Ta'a M.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14093224"},{"key":"e_1_2_11_5_1","first-page":"90","article-title":"Leukocyte\u2010Platelet Rich Fibrin (L\u2010PRF) in Combination With Tunneling Technique in Management of Gingival Recession: Randomized Clinical Study","volume":"13","author":"Ahmed E. 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