{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:15:33Z","timestamp":1788279333480,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To compare post\u2010cementation sensitivity between resin\u2010modified glass ionomer cement (RMGIC) and conventional glass ionomer cement (GIC) used as luting agents for single crowns.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n This randomized controlled trial was conducted at Saidu College of Dentistry, Swat, Pakistan. A total of 496 eligible participants were randomized into two groups: GIC (\n n<\/jats:italic>\n \u2009=\u2009248) and RMGIC (\n n<\/jats:italic>\n \u2009=\u2009248). Post\u2010cementation sensitivity was recorded at 24\u2009h, 1 week, and 1 month using a 10\u2010point visual analog scale (VAS), with scores categorized as no, mild, moderate, or severe sensitivity. Data were analyzed using Mann\u2013Whitney\n U<\/jats:italic>\n tests, and linear mixed\u2010effects models adjusted for age, gender, jaw, and prosthesis location.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Baseline demographic and clinical characteristics were comparable between groups. Post\u2010cementation sensitivity was consistently lower in the RMGIC group compared to the GIC group across all time points. Median sensitivity scores at 24\u2009h were 4.0 (GIC) versus 3.0 (RMGIC,\n p<\/jats:italic>\n \u2009<\u20090.001); at 1 week, 2.0 versus 1.0 (\n p<\/jats:italic>\n \u2009<\u20090.001); and at 1 month, both minimal but significantly lower in the RMGIC group (\n p<\/jats:italic>\n \u2009<\u20090.001). The adjusted mixed\u2010effects model confirmed that RMGIC significantly reduced sensitivity compared to GIC (\n \u03b2<\/jats:italic>\n \u2009=\u2009\u22120.53; OR 0.59, 95% CI 0.46\u20130.75;\n p<\/jats:italic>\n \u2009<\u20090.001). Sensitivity was highest at 24\u2009h (\n \u03b2<\/jats:italic>\n \u2009=\u20092.96; OR 19.3, 95% CI 15.3\u201324.3;\n p<\/jats:italic>\n \u2009<\u20090.001), followed by 1 week (\n \u03b2<\/jats:italic>\n \u2009=\u20090.81; OR 2.25, 95% CI 1.77\u20132.86;\n p<\/jats:italic>\n \u2009<\u20090.001), and declined markedly by 1 month. Age showed a modest protective effect (\n \u03b2<\/jats:italic>\n \u2009=\u2009\u22120.008; OR 0.99, 95% CI 0.99\u20131.00;\n p<\/jats:italic>\n \u2009=\u20090.04), while gender, jaw, and prosthesis location were not significant predictors. A significant interaction at 24\u2009h showed RMGIC provided an additional reduction in sensitivity compared to GIC (\n \u03b2<\/jats:italic>\n \u2009=\u2009\u22120.83; OR 0.44, 95% CI 0.31\u20130.61;\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n RMGIC demonstrated significantly lower post\u2010cementation sensitivity compared to conventional GIC.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n This trial was retrospectively registered with Clinical Trials Registry of ClinicalTrials.gov(registration#NCT07102121) on August 3, 2025.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cre2.70339","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:25:13Z","timestamp":1774952713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Post\u2010Cementation Sensitivity Between Resin Modified Glass Ionomer Cement and Conventional Glass Ionomer Cement as a Luting Material\u2014A Randomized Clinical Trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-3852","authenticated-orcid":false,"given":"Shamsul","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Public Health Khyber Medical University Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4141-0714","authenticated-orcid":false,"given":"Naveed","family":"Sadiq","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Social Sciences Khyber Medical University Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6816-653X","authenticated-orcid":false,"given":"Hend Mohamed","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Restorative Dentistry, Department of Restorative and Prosthetic Dental Sciences, College of Dentistry Dar Al Uloom University Riyadh Saudi\u00a0Arabia"},{"name":"Restorative Dentistry, Department of Restorative and Prosthetic Dental Sciences, College of Dentistry Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4197-6876","authenticated-orcid":false,"given":"Sheema","family":"Shakir","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Khyber College of Dentistry Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2521-5281","authenticated-orcid":false,"given":"Nasser Hussein","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Restorative and Prosthetic Dental Sciences Department Dar Al Uloom University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-5900","authenticated-orcid":false,"given":"Ahmed Mohammed","family":"Elmarakby","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Faculty of Dental Medicine Al Azhar University, Assiut Branch Cairo Egypt"},{"name":"Department of Restorative and Prosthetic Dental Sciences, College of Dentistry Dar Al Uloom University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-3349","authenticated-orcid":false,"given":"Asif","family":"Rehman","sequence":"additional","affiliation":[{"name":"Bath Spa University Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj7030071"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2020.04.010"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1850"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8101687"},{"key":"e_1_2_14_6_1","first-page":"1001","article-title":"Modification of Glass Ionomer Restorative Material: A Review of Literature","volume":"18","author":"Bakhadher W.","year":"2019","journal-title":"EC Dental Science"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0775-4"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-015-0162-z"},{"issue":"1","key":"e_1_2_14_9_1","first-page":"73","article-title":"Clinical Comparison of Postoperative Sensitivity for an Adhesive Resin Cement Containing 4\u2010META and a Conventional Glass\u2010Ionomer Cement","volume":"20","author":"Denner N.","year":"2007","journal-title":"International Journal of Prosthodontics"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.62513"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1416"},{"key":"e_1_2_14_12_1","first-page":"241","article-title":"A Clinical Comparison of Two Cements for Levels of Post\u2010Operative Sensitivity in a Practice\u2010Based Setting","volume":"29","author":"Hilton T.","year":"2004","journal-title":"Operative Dentistry"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-081124"},{"issue":"4","key":"e_1_2_14_14_1","first-page":"519","article-title":"Experience of Post Cementation Hypersensitivity: A Kap Study Done on Dentists & Faculty in Rawalpindi Islamabad","volume":"38","author":"Iqbal H.","year":"2018","journal-title":"Pakistan Oral & Dental Journal"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2000.00321.x"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.07.003"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1146"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-3797"},{"key":"e_1_2_14_19_1","first-page":"327","article-title":"Comparative Analysis of Postcementation Hypersensitivity With Glass Ionomer Cement and a Resin Cement: An In Vivo Study","volume":"13","author":"Shetty R. M.","year":"2009","journal-title":"Journal of Contemporary Dental Practice"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2009.08.015"},{"issue":"5","key":"e_1_2_14_21_1","first-page":"34","article-title":"Clinical Evaluation of a New Resin Composite Crown System to Eliminate Postoperative Sensitivity","volume":"20","author":"Suzuki S.","year":"2000","journal-title":"International Journal of Periodontics & Restorative Dentistry"},{"issue":"4","key":"e_1_2_14_22_1","first-page":"1123","article-title":"A New Landscape of Human Dental Aging: Causes, Consequences, and Intervention Avenues","volume":"14","author":"Xie Y.","year":"2023","journal-title":"Aging and Disease"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cre2.70339","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:18:37Z","timestamp":1788275917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/cre2.70339"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70339","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"2025-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70339"}}