{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:45:08Z","timestamp":1782740708409,"version":"3.54.5"},"reference-count":140,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro\u2010inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis\u2010associated bacteria and HNSCC, focusing on their impact on oncogenic pathways, immune modulation, and epigenetic alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A comprehensive search of PubMed and Google Scholar was conducted up to January 28, 2026, without time limitations, using all relevant keywords related to HNSCC, head and neck cancers, periodontitis, and the oral microbiome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Key periodontitis\u2010associated bacteria, including\u202f\n                      <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                      ,\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      ,\n                      <jats:italic>Capnocytophaga gingivalis<\/jats:italic>\n                      , and\u202f\n                      <jats:italic>Prevotella intermedia<\/jats:italic>\n                      , may play a vital role in HNSCC. These bacteria stimulate several oncogenic pathways, including Wnt\/\u03b2\u2010catenin, NF\u2010\u03baB, and PI3K\/Akt, enabling HNSCC to evade immune responses, trigger epithelial\u2010to\u2010mesenchymal transition and angiogenesis, and encourage cell proliferation and stemness. Furthermore, microbial interactions within the tumor microenvironment significantly impact treatment resistance, particularly in the context of immune checkpoint inhibitor therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Incorporating periodontal screening, microbiome profiling, and bacterial\u2010targeted therapies into oncology could enhance treatment outcomes for HNSCC. Future research should investigate CRISPR\u2010based microbial interventions, targeted epigenetic therapies, and microbiome\u2010driven precision oncology strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70341","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:05:04Z","timestamp":1777842304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9590-2935","authenticated-orcid":false,"given":"Yashmin","family":"Afshar","sequence":"first","affiliation":[{"name":"Cancer Immunology Project (CIP) Universal Scientific Education and Research Network (USERN) Tehran 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