{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:15:47Z","timestamp":1788279347363,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"publisher","award":["69\u2010143"],"award-info":[{"award-number":["69\u2010143"]}],"id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"publisher","award":["69\u2010145"],"award-info":[{"award-number":["69\u2010145"]}],"id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Cleidocranial dysplasia (CCD) is a rare\n                      <jats:italic>RUNX2<\/jats:italic>\n                      \u2010related skeletal disorder characterized by craniofacial anomalies and skeletal Class III malocclusion. However, the relationship between\n                      <jats:italic>RUNX2<\/jats:italic>\n                      variant type and phenotype severity remains unclear. This study aimed to evaluate the association between\n                      <jats:italic>RUNX2<\/jats:italic>\n                      variant types and the severity of skeletal Class III malocclusion and dental anomalies in CCD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      This cross\u2010sectional study included 11 unrelated Thai CCD probands and 14 relatives who underwent exome or genome sequencing.\n                      <jats:italic>RUNX2<\/jats:italic>\n                      variants were classified as non\u2010truncating or truncating\/structural according to ACMG\u2010AMP criteria. Nine genetically confirmed individuals met the inclusion criteria for radiographic analysis. Craniofacial parameters and dental anomalies were assessed using lateral cephalograms and cone\u2010beam computed tomography. Group comparisons were performed using nonparametric tests and correlation analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Truncating\/structural variants were associated with shorter cranial base length, smaller SNA, and reduced nasolabial angles compared with non\u2010truncating variants. The variant type correlated with these parameters. Skeletal Class III malocclusion was present in both groups, predominantly due to mandibular prognathism. No significant association was found between variant type and the burden or distribution of dental anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>RUNX2<\/jats:italic>\n                      variant type influences cranial base and maxillary morphology, contributing to skeletal Class III severity in CCD, whereas dental anomalies appear independent of variant type.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70351","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:44:42Z","timestamp":1776429882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of\n                    <i>RUNX2<\/i>\n                    Variants With Craniofacial\u2013Dental Phenotypes in Cleidocranial Dysplasia"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6866-5592","authenticated-orcid":false,"given":"Pintu\u2010on","family":"Chantarawaratit","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0327-5320","authenticated-orcid":false,"given":"Sermporn","family":"Thaweesapphithak","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Geriatric Dentistry and Special Patients Care Program, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"},{"name":"Department of Oral Biology, International College of Dentistry Walailak University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-5450","authenticated-orcid":false,"given":"Pisha","family":"Pittayapat","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-9801","authenticated-orcid":false,"given":"Thantrira","family":"Porntaveetus","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Geriatric Dentistry and Special Patients Care Program, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"},{"name":"Clinic of General, Special Care and Geriatric Dentistry, Center for Dental Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01862.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(63)90220-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2006.00399.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2022.10.011"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2011.09.002"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15077"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02907-5"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2319\/111307-393.1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004200"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12812"},{"issue":"3","key":"e_1_2_12_12_1","first-page":"163","article-title":"Cleidocranial Dysplasia: Craniofacial Morphology in Adult Patients","volume":"14","author":"Jensen B. 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