{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:45:06Z","timestamp":1782740706018,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Direct pulp capping (DPC) preserves pulp vitality in caries\u2010exposed permanent teeth, but clinical evidence comparing different capping materials and identifying prognostic factors remains limited. This study evaluated the success of DPC with iRoot BP Plus, mineral trioxide aggregate (MTA), and calcium hydroxide (CH), and explored factors associated with treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>In this single\u2010blind, parallel\u2010group, superiority randomized trial, 120 patients with caries\u2010induced reversible pulpitis were equally assigned to CH, MTA, or iRoot BP Plus. The primary outcome was 12\u2010month success, defined by combined clinical and radiographic criteria. Associations between baseline clinical factors and 12\u2010month success were evaluated. Secondary analyses included success at 3 and 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 12 months, 81 of 120 randomized patients (67.5%) were available for evaluation. The overall success rate was 88.9%. Success rates were 88.5% for iRoot BP Plus (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926), 93.1% for MTA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929), and 84.6% for CH (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926), with no significant differences between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.6). Failures were significantly associated with lesions confined to the proximal surface (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) at 12 months, while exposure size &gt;\u20091\u2009mm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024) and anterior teeth (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018) were additional risk factors at 6 months. Kaplan\u2013Meier analysis showed high survival across all groups (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.66) and confirmed the influence of these risk factors. No adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DPC achieved high short\u2010term success in mature permanent teeth in MTA, CH, and iRoot BP Plus. Prognostic factors such as caries location, tooth position, and exposure size remain critical for case selection.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      number: ChiCTR2100047588; Chinese Clinical Trial Register.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70367","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T14:23:49Z","timestamp":1779805429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Evaluation of Three Direct Pulp Capping Materials in Caries\u2010Induced Pulpitis of Mature Permanent Teeth: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3528-1294","authenticated-orcid":false,"given":"Yutong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangrui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boshu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongyi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwei","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"American Association of Endodontists.2020. \u201cGlossary of Endodontic Terms.\u201d 10th Edition. 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