{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:44:36Z","timestamp":1792071876596,"version":"4.4.0"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This case series reports on alveolar osteitis (AO) treatment outcomes after standard AO therapy combined with cross\u2010linked hyaluronic acid (xHyA) and a collagen sponge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Nine patients fulfilling the AO criteria after permanent tooth extraction were included. After standard AO treatment, that is, irrigation and curettage, a xHyA gel combined with an absorbable collagen sponge was applied into the socket and stabilized with a suture. Pain perception (visual analogue scale [VAS], pain killer consumption), soft tissue healing index (STHI), alveolar bone exposure, necessity of re\u2010treatment, occurrence of complications, and patients\u2019 opinion were assessed up to 14 days post\u2010treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight patients completed the 14\u2010day follow\u2010up, while one patient dropped out after 1 day due to persisting pain. Initial mean pain perception (VAS) was 7.5 (1.4), which decreased after a single treatment to 4.4 (2.2) within 6\u2009h and by 50% (3.8 [2.4]) within 24\u2009h. In 5 out of 8 patients, complete pain resolution was achieved after 14 days, while 3 patients still experienced moderate pain. Pain reduction was accompanied by an improvement of STHI, reaching 4.0 (0.8) within 14 days; complete coverage of exposed alveolar bone walls was already observed within 3 days in all 8 patients. Only one patient required re\u2010treatment; 5 out of 8 patients expressed willingness to pay on top between 50 and 300\u20ac for the material costs (xHyA+collagen sponge).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A single application of xHyA combined with a collagen sponge offered effective and fast pain relief combined with a favorable healing process in patients suffering from AO. Furthermore, the need for re\u2010treatment was infrequent, and favorable patient feedback was observed. However, randomized controlled trials with a sufficient sample size and a control group are essential to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70388","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:43:41Z","timestamp":1786387421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Prospective Case Series on the Effect of Cross\u2010Linked Hyaluronic Acid Combined With a Collagen Sponge in the Treatment of Alveolar Osteitis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7799-6629","authenticated-orcid":false,"given":"Danijel","family":"Domic","sequence":"first","affiliation":[{"name":"Division of Oral Surgery University Clinic of Dentistry, Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4857-7159","authenticated-orcid":false,"given":"Peter","family":"Bauer","sequence":"additional","affiliation":[{"name":"Division of Oral Surgery University Clinic of Dentistry, Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9518-4880","authenticated-orcid":false,"given":"Nicola","family":"Ottenbacher","sequence":"additional","affiliation":[{"name":"Division of Oral Surgery University Clinic of Dentistry, Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-7943","authenticated-orcid":false,"given":"Kristina","family":"Bertl","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Clinic, Faculty of Medicine Sigmund Freud University Vienna Austria"},{"name":"Department of Periodontology Blekinge Hospital Karlskrona Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2396-8773","authenticated-orcid":false,"given":"Christian","family":"Ulm","sequence":"additional","affiliation":[{"name":"Division of Oral Surgery University Clinic of Dentistry, Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-3754","authenticated-orcid":false,"given":"Andreas","family":"Stavropoulos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Blekinge Hospital Karlskrona Sweden"},{"name":"Periodontology, Faculty of Odontology University of Malm\u00f6 Malm\u00f6 Sweden"},{"name":"Division of Conservative Dentistry and Periodontology University Clinic of Dentistry, Medical University of Vienna Vienna Austria"},{"name":"Department of Periodontology, School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.11.023"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.11.005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024111430856"},{"key":"e_1_2_12_5_1","article-title":"Comparative Clinical Study Between Chlorhexidine Gel (0.2%) and Hyaluronic Gel (1%) in the Prevention of a Dry Socket After Tooth Extraction for Orthodontic Treatment","volume":"14","author":"Almushalbn A.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12602"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1988.tb01020.x"},{"key":"e_1_2_12_8_1","first-page":"1","article-title":"International Journal of Dentistry and Oral Health Open Access The Effects of Using Hyaluronic Acid on the Extraction Sockets","volume":"2","author":"Bayoumi A.","year":"2015","journal-title":"International Journal of Dentistry and Oral Health"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0263"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201003963"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9095"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.12.005"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2017.43.3.160"},{"key":"e_1_2_12_14_1","first-page":"203","article-title":"Comparative Study to Determine the Efficacy of Zinc Oxide Eugenol and Alveogyl in Treatment of Dry Socket","volume":"15","author":"Chaurasia N. 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