{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:45:09Z","timestamp":1782740709986,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the development of oral premalignant and malignant lesions as a major long\u2010term complication following hematopoietic stem cell transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center retrospective study identified 17 patients who developed 26 pathology\u2010confirmed oral premalignant and malignant lesions after hematopoietic stem cell transplantation, with a latency period ranged from 5 months to nearly 18 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve high\u2010grade lesions developed in nine patients at a median of 9 years post\u2010hematopoietic stem cell transplantation, most commonly on the tongue. All high\u2010grade lesions were surgically treated, with complete response in most cases. One patient developed nodal disease 9.6 years after surgery, and another experienced local recurrence of moderate dysplasia 2 years post\u2010treatment, which was controlled by cryogun cryotherapy. Most patients had chronic graft\u2010versus\u2010host disease and histories of immunosuppressant therapy. Cryogun cryotherapy was used to treat 10 premalignant lesions across seven patients, involving the tongue, gingiva, and buccal or labial mucosa. This treatment achieved an 80% complete response rate with minimal scarring. Verrucous hyperplasia was the most common diagnosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Routine, long\u2010term oral screening is critical for patients after hematopoietic stem cell transplantation. Cryogun cryotherapy shows promise as an effective, minimally invasive option for managing early oral verrucous lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70389","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T18:27:55Z","timestamp":1781548075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Lesions Developed in Post\u2010Hematopoietic Stem Cell Transplant Patients and the Role of Cryogun Cryotherapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Pei Hsuan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital Yun Lin Branch Douliu Taiwan"},{"name":"Department of Dentistry, National Taiwan University Hospital, College of Medicine National Taiwan University Taipei Taiwan"},{"name":"School of Dentistry, Graduate Institute of Clinical Dentistry National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly Yi Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Oral Medical and Biological Sciences University of British Columbia Vancouver British Columbia Canada"},{"name":"Basic and Translation Research BC Cancer Research Centre Vancouver British Columbia Canada"},{"name":"School of Biomedical Engineering, Faculty of Medicine University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samson P.","family":"Ng","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Oral Medical and Biological Sciences University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine F.","family":"Poh","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Oral Medical and Biological Sciences University of British Columbia Vancouver British Columbia Canada"},{"name":"Basic and Translation Research BC Cancer Research Centre Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.10.021"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-344390"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.108"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2015.03.002"},{"issue":"7","key":"e_1_2_10_6_1","first-page":"399","article-title":"Cutaneous Cryosurgery for Common Skin Conditions","volume":"101","author":"Clebak K. 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