{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:45:14Z","timestamp":1782740714984,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study investigated the effectiveness of biofilm removal using individually customized cleaning splints (CS) as an aid for interdental brushes (IDBs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In a randomized clinical crossover study, the effect of IDBs in combination with CS on plaque reduction and periodontal parameters was examined. Periodontitis patients received an intraoral scan to produce a 3D\u2010printed CS. Following a 2\u2010week interdental hygiene pause, they were divided into two groups: Group A: CS+IDBs, Group B: IDBs. Participants performed daily interdental cleaning at home for 2 weeks following standardized professional instruction. After another 2\u2010week interdental hygiene pause, the groups switched methods. Additionally, motor skills, stress levels, and nutritional quality were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty participants (age range 21\u201382 years) completed the study. CS+IDBs led to a significantly greater plaque reduction (change in Quigley\u2013Hein plaque index, \u2206QHI) compared to IDBs alone (\u0394QHI = \u22121.38 vs. \u22120.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The impact on reducing gingival inflammation (GI) was limited to younger participants with no effect on bleeding on probing (BOP). Random effects ANCOVA confirmed the significant effect of CS on \u2206QHI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). An interaction between perceived stress and CS use on BOP indicated that stress may influence the effectiveness of CS supported plaque removal.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cleaning splints are a promising approach to enhance the effectiveness of IDBs in reducing interdental biofilm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70392","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:25:22Z","timestamp":1782239122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of 3D\u2010Printed Cleaning Splints for Approximal Dental Biofilm Removal\u2014A Randomized Clinical Crossover Pilot Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8765-3754","authenticated-orcid":false,"given":"Marcia","family":"Spindler","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry, Heidelberg Faculty of Medicine Heidelberg University Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Heidelberg Faculty of Medicine Heidelberg University Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9515-4405","authenticated-orcid":false,"given":"Stefan","family":"Rues","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, Heidelberg Faculty of Medicine Heidelberg University Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, Heidelberg Faculty of Medicine Heidelberg University Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rammelsberg","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, Heidelberg Faculty of Medicine Heidelberg University Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zenth\u00f6fer","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, Heidelberg Faculty of Medicine Heidelberg University Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Heidelberg Faculty of Medicine Heidelberg University Heidelberg 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Putzschiene \u2010 ein effizientes Mundhygienehilfsmittel bei Teil\u2010 und Deckprothesen","volume":"63","author":"Kern M.","year":"2012","journal-title":"Die Quintessenz"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa209"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1965.36.3.177"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-6-s1-s14"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072025"},{"issue":"2","key":"e_1_2_12_20_1","first-page":"213","article-title":"Gedruckte Putzschienen als Mundhygienehilfsmittel in der Teil\u2010 und Implantatprothetik","volume":"29","author":"Passia 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