{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:44:34Z","timestamp":1792071874344,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review aims to assess the effectiveness of varnishes for the remineralization of white spot lesions in primary teeth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A database search was conducted in MEDLINE and the Cochrane Library to screen for articles relevant to the topic of the review. Risks of bias in randomized studies were assessed using the ROB2 tool and GRADE evidence levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven studies met all inclusion criteria and were included. Differences in varnish composition and characteristics can affect the anticaries properties. Bioactive additives had a statistically significant reduction in ICDAS scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intensive application of remineralizing varnishes demonstrated a significant effect on the remineralization and control of carious lesion activity. New\u2010generation fluoride appear to be more effective than conventional sodium fluoride varnishes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70403","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:33:31Z","timestamp":1783542811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness in Remineralizing White Spot Lesions in Primary Teeth With Varnishes: A Systematic Review"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8005-3775","authenticated-orcid":false,"given":"Carolina","family":"Caleza\u2010Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Department of Stomatology University of Seville Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4511-0145","authenticated-orcid":false,"given":"Mar\u00eda","family":"Biedma\u2010Perea","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Seville Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-9216","authenticated-orcid":false,"given":"David","family":"Ribas\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Seville Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6178-7033","authenticated-orcid":false,"given":"Maria Jos\u00e9","family":"Barra\u2010Soto","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Seville Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-7187","authenticated-orcid":false,"given":"Marcela","family":"Arenas\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Seville Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"49","article-title":"Policy on Use of Fluoride. 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