{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:44:34Z","timestamp":1792071874359,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      It is well known that\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      , a major pathogen in periodontitis, causes systemic diseases. This study investigated the expression of PGC\u20101\u03b1 (the most important factor in muscle mitochondria synthesis) following endurance training to clarify the relationship between\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      infection and muscle endurance capacity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Twenty 8\u2010week\u2010old Wistar rats were randomly divided into two groups. One group was intraperitoneally administered sonicated\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      (\n                      <jats:italic>P. g<\/jats:italic>\n                      \u2010group), and the other group was administered saline (Control\u2010group). Three weeks after administration, gastrocnemius muscles and blood from both groups were collected 24\u2009h after treadmill exercise. The expressions of PGC\u20101\u03b1 and TNF\u2010\u03b1 in gastrocnemius muscle were measured, along with serum antibody titers for IgG, in response to\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum IgG antibody titers and TNF\u2010\u03b1 expression in skeletal muscle were significantly higher in the\n                      <jats:italic>P. g<\/jats:italic>\n                      \u2010group than in the Control\u2010group. PGC\u20101\u03b1 expression was significantly lower in the\n                      <jats:italic>P. g<\/jats:italic>\n                      \u2010group than in the Control\u2010group. A correlation was observed between PGC\u20101\u03b1 and TNF\u2010\u03b1 expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our result suggests that the increase in endurance following training may be suppressed by\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70415","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:16:29Z","timestamp":1784225789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of\n                    <i>Porphyromonas gingivalis<\/i>\n                    Infection on PGC\u20101\u03b1 in Skeletal Muscle After Endurance Training In Vivo"],"prefix":"10.1002","volume":"12","author":[{"given":"Kairi","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Masticatory Function and Health Science Graduate School of Medical and Dental Sciences, Institute of Science Tokyo Tokyo Japan"},{"name":"Division of Sports Dentistry Sports Science Organization, Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4193-219X","authenticated-orcid":false,"given":"Yasuo","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Lifetime Oral Health Care Science Graduate School of Medical and Dental Sciences, Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0631-6570","authenticated-orcid":false,"given":"Hiroaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences, Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Sports Dentistry Meikai University School of Dentistry Sakado Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-1192","authenticated-orcid":false,"given":"Hiroshi","family":"Churei","sequence":"additional","affiliation":[{"name":"Department of Masticatory Function and Health Science Graduate School of Medical and Dental Sciences, Institute of Science Tokyo Tokyo Japan"},{"name":"Division of Sports Dentistry Sports Science Organization, Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Sports Dentistry Meikai University School of Dentistry Sakado Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Fueki","sequence":"additional","affiliation":[{"name":"Department of Masticatory Function and Health Science Graduate School of Medical and Dental Sciences, Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2019-0248"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.12.8296"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2018.1396876"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00840"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040543"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-216972"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0143-2885.2001.00489.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-019-03532-9"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2030341"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2873"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900524"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192013046"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00113.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.681"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.7.618"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ16-0126"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0377-1"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-020-00878-0"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26521"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13044"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0834-0"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v8.30385"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn327"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2342-y"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13189"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1998.tb02419.x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2016.24.215.8727"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2018.1426876"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00963.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001158R"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.2.935-943.2005"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cre2.70415","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:48:35Z","timestamp":1792068515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/cre2.70415"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70415","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"assertion":[{"value":"2025-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70415"}}