{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:44:30Z","timestamp":1792071870856,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review evaluated the diagnostic accuracy of CBCT for BMD assessment using DEXA as the reference standard and aimed to quantify its performance through meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This review included prospective and retrospective observational studies assessing CBCT's diagnostic performance in detecting low BMD, with DEXA as the reference. Searches in PubMed, Embase, and Scopus identified 13 eligible studies involving adult participants (\u2265\u200918 years). Two reviewers independently extracted data and assessed study quality using the QUADAS\u20102 tool. Meta\u2010analysis was conducted using random\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pooled sensitivity and specificity of CBCT for detecting low BMD were 0.58 (95% CI: 0.50\u20130.67) and 0.78 (95% CI: 0.69\u20130.86), respectively. The summary receiver operating characteristic (SROC) curve showed an area under the curve (AUC) of 0.73 (95% CI: 0.69\u20130.77), indicating moderate diagnostic accuracy. Subgroup analyses revealed heterogeneity influenced by sample size and anatomical site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CBCT demonstrates moderate diagnostic accuracy in detecting low BMD, with better specificity than sensitivity. While promising, standardization of CBCT protocols and larger studies are needed to confirm its role in clinical assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO Registration Number<\/jats:title>\n                    <jats:p>(CRD42024598958).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70423","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:29:21Z","timestamp":1785587361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Diagnostic Performance of Cone Beam Computed Tomography and Dual\u2010Energy X\u2010Ray Absorptiometry for Low Bone Density Assessment. A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5193-6976","authenticated-orcid":false,"given":"Mohammad","family":"Alrashidi","sequence":"first","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-7822","authenticated-orcid":false,"given":"Haitham","family":"Elbishari","sequence":"additional","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAE"},{"name":"School of Medicine, Dentistry and Biomedical Sciences Queen's University Belfast Belfast UK"},{"name":"The Faculty of Biology, Medicine and Health The University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4629-0635","authenticated-orcid":false,"given":"May","family":"Aljanahi","sequence":"additional","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAE"},{"name":"School of Medicine, Dentistry and Biomedical Sciences Queen's University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-6068","authenticated-orcid":false,"given":"Fatemeh","family":"Amir\u2010Rad","sequence":"additional","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAE"},{"name":"School of Medicine, Dentistry and Biomedical Sciences Queen's University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9022-9631","authenticated-orcid":false,"given":"Jahanzeb","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-9491","authenticated-orcid":false,"given":"Momen","family":"Atieh","sequence":"additional","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAE"},{"name":"Faculty of Dentistry, Sir John Walsh Research Institute University of Otago Dunedin New Zealand"},{"name":"School of Dentistry The University of Jordan Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2019.07.013"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.5624\/isd.2014.44.4.263"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12170"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.08.008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2022.vol36.0138"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.07.016"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1258"},{"issue":"4","key":"e_1_2_12_9_1","first-page":"456","article-title":"Bone Quality in Competitive Athletes: A Systematic Review","volume":"23","author":"Burt L. A.","year":"2023","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.5624\/isd.20210172"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03193-4"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2794-2"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2016.11.005"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.15171\/joddd.2017.034"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.21608\/erurj.2023.211464.1026"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13105962"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.16.00749"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2008.07.017"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20160475"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.15-0609"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0172-4"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20180254"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa632"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19163"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532-3382(01)70024-3"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12185890"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090802"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.11.024"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12193"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.21767\/2471-299X.1000057"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2019.04.017"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2021.06.014"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj11010017"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1501-1"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cre2.70423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.70423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:48:10Z","timestamp":1792068490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.70423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/cre2.70423"],"URL":"https:\/\/doi.org\/10.1002\/cre2.70423","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70423"}}