{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:44:36Z","timestamp":1792071876085,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the available clinical evidence on the use of ozonated gels and oils in the management of periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Embase, SCOPUS, Web of Science, PubMed, and Google Scholar were searched up to May 13, 2025. Original peer\u2010reviewed randomized controlled trials (RCTs) in English that investigated patients with periodontitis were included. Study characteristics, methods of ozone application, conclusions, and reported complications were extracted. Pooled mean differences of clinical indices were compared between the ozone therapy groups (adjunctive or monotherapy) and control groups (placebo or CHX). Primary outcomes included clinical indices such as probing pocket depth (PPD), plaque index (PI), and gingival index (GI), whereas secondary outcomes comprised clinical attachment level (CAL), clinical attachment loss (CAtL), bleeding on probing (BoP), and sulcus bleeding index (SBI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 962 records, 19 clinical studies were included in the qualitative synthesis and 18 RCTs in the quantitative synthesis. For periodontitis, ozonated compounds significantly reduced PPD when used as an adjunct to subgingival instrumentation (MD\u2009=\u2009\u22120.780;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and reduced clinical attachment loss (CAL) (MD\u2009=\u2009\u22120.457;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) compared with subgingival instrumentation alone. No statistically significant differences were observed in PI or GI outcomes with ozonated compounds as an adjunct to subgingival instrumentation compared with subgingival instrumentation alone, although sensitivity analyses indicated some instability in the results. Follow\u2010up periods ranged from 4 to 12 weeks across outcomes (8\u201312 weeks for GI), with most studies reporting 12\u2010week follow\u2010up. No consistent differences were found between ozone and CHX in terms of PPD, CAL, PI or BoP. No adverse effects were reported in the studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ozonated gels and oils were associated with favorable periodontal outcomes, particularly when used as adjuncts to subgingival instrumentation, and no major adverse effects were reported. However, the evidence is limited by short\u2010term follow\u2010up and methodological heterogeneity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70439","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:28:57Z","timestamp":1787682537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Ozonated Gels and Oils As Adjunctive or Monotherapy in Periodontitis: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2672-2746","authenticated-orcid":false,"given":"Mahdi","family":"Bahrami","sequence":"first","affiliation":[{"name":"Student Research Committee, Faculty of Dentistry Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-947X","authenticated-orcid":false,"given":"Mahsa","family":"Etemadi","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dentistry Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyhaneh","family":"Abrishami","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Dentistry Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1021-5944","authenticated-orcid":false,"given":"Farshad","family":"Alipour","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Dentistry Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Hadizadeh","sequence":"additional","affiliation":[{"name":"Women Reproductive Health Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7856-1501","authenticated-orcid":false,"given":"Faezeh","family":"Jamshidian","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Dentistry Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1993-9997","authenticated-orcid":false,"given":"Nooshin","family":"Abedinzadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Dentistry Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-3018","authenticated-orcid":false,"given":"Abolfazl","family":"Akbari","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Dentistry Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9225-6163","authenticated-orcid":false,"given":"Edris","family":"Pordel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Dental School Sabzevar University of Medical Sciences Sabzevar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.9734\/jpri\/2021\/v33i62B35627"},{"issue":"2","key":"e_1_2_12_3_1","first-page":"647","article-title":"The Efficiency of Ozonated Gel Vs Chlorhexidine Gel as Adjunct Treatment to Control Plaque\u2010Induced Gingivitis Assessed by interleukin\u20101\u03b2 Levels in Gingival Crevicular Fluid (A Comparative Clinical Trial)","volume":"11","author":"AL\u2010Chalabi M. 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