{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:07:00Z","timestamp":1789376820181,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To delineate the craniofacial morphometric characteristics of Thai children with syndromic (SC) and non\u2010syndromic craniosynostosis (NSC) and to assess dental maturation relative to Chronological Age (CA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This comparative cross\u2010sectional study evaluated 19 patients (SC:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913; NSC:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096; mean age 9.32\u2009\u00b1\u20092.67 years). Seventeen skeletal and dental cephalometric variables were analyzed against age\u2010matched ethnic norms. Dental age (DA) was quantified using the modified Demirjian's four\u2010tooth method, calibrated via the Thai\u2010specific Duangto model. One\u2010sample and Welch's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests compared DA with CA and skeletal parameters with normative data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SC patients demonstrated significant maxillary retrusion and midface hypoplasia, characterized by reduced SNA (73.63\u2009\u00b1\u20099.52\u00b0), ANB (\u22127.1\u2009\u00b1\u200910.51\u00b0), and maxillary depth (79.36\u2009\u00b1\u200911.2\u00b0) compared to normative data (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Additionally, the SC group exhibited a hyperdivergent growth pattern (increased FMA: 32.61\u2009\u00b1\u20096.87\u00b0), a shortened anterior cranial base (41.47\u2009\u00b1\u20094.56\u2009mm), and compensatory mandibular incisor retroclination (IMPA: 88.38\u2009\u00b1\u20098.57\u00b0) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In contrast, the NSC phenotype was primarily localized to a shortened anterior cranial base (48.17\u2009\u00b1\u20095.66\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), with other skeletal parameters remaining within normative ranges. When evaluating dental maturation relative to chronological age, no statistically significant differences were detected in either cohort (mean difference: SC\u2009=\u20090.09\u2009\u00b1\u20091.50 years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05; NSC\u2009=\u20091.23\u2009\u00b1\u20091.61 years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with SC present with severe multi\u2010planar skeletal discrepancies and secondary dental compensations, whereas NSC\u2010related dysmorphology is primarily confined to the cranial base. No statistically significant differences were detected between DA and CA in either group. Because dental development does not necessarily reflect the extent of craniofacial skeletal discrepancies, treatment timing must instead rely on comprehensive, patient\u2010specific structures and skeletal malocclusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70445","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:48:16Z","timestamp":1789375696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Craniofacial Morphology and Dental Age Assessment in Pediatric Craniosynostosis: A Comparative Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0518-6695","authenticated-orcid":false,"given":"Nutthakarn","family":"Ratanasereeprasert","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"},{"name":"Center of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanisa","family":"Wongbanthit","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"},{"name":"Clinic of General, Special Care and Geriatric Dentistry, Center for Dental Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7504-1403","authenticated-orcid":false,"given":"Narin","family":"Intarak","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeya","family":"Suwanwitid","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chutimont","family":"Teekavanich","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2009-4393","authenticated-orcid":false,"given":"Anand","family":"Marya","sequence":"additional","affiliation":[{"name":"Orthodontics, Faculty of Dentistry University of Puthisastra Phnom Penh Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6620-1302","authenticated-orcid":false,"given":"Guang","family":"Hong","sequence":"additional","affiliation":[{"name":"Division for Globalization Initiative, Graduate School of Dentistry Tohoku University Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-9801","authenticated-orcid":false,"given":"Thantrira","family":"Porntaveetus","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"},{"name":"Clinic of General, Special Care and Geriatric Dentistry, Center for Dental Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/00368504231156297"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-02779-5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368-013-0105-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.13146"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04275-y"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014467600001671"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-018-1805-9"},{"issue":"7","key":"e_1_2_12_9_1","first-page":"217","article-title":"Functional Growth Boundaries in the Human and Mammalian Face","volume":"11","author":"Enlow D. 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