{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:04:54Z","timestamp":1789499094284,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Polyphenols have been investigated in dental materials and restorative techniques due to their interactions with metal cations, antioxidant activity, and collagen crosslinking ability, which make them a promise for reinforcing the dental substrate and improving material adhesion. However, more studies are necessary before to support their use in clinical procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study evaluated the effects of quercetin and resveratrol on bond strength and the protection of dentin collagen fibrils against enzymatic degradation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Demineralized human dentin specimens were immersed for 1\u2009min in solutions of quercetin or resveratrol (100, 250, and 500\u2009\u00b5g\/mL), 2% chlorhexidine (CHX), or 0.9% saline (control). The specimens were then incubated in collagenase for 24\u2009h at 37\u00b0C, and changes in dry mass were measured. For microtensile bond strength testing, quercetin, resveratrol, CHX, or distilled water (DW) were applied to phosphoric acid\u2013conditioned dentin, followed by application of Single Bond 2 (3\u2009M\/ESPE) adhesive and Z350XT resin (3\u2009M\/ESPE). Adhesive strength was measured after 24\u2009h and after 1 year in distilled water. Data were analyzed using the Kruskal\u2013Wallis and Dunn tests or ANOVA followed by Tukey's test (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Quercetin\u2010treated specimens showed a significant weight increase compared with CHX (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Both quercetin\u2010 and resveratrol\u2010treated groups exhibited resistance to collagenase similar to CHX (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). After 1 year, only the DW group showed a significant decrease in bond strength (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dentin treatment with quercetin or resveratrol effectively preserved adhesive strength and protected collagen against enzymatic degradation, suggesting their potential as agents to improve the longevity of adhesive restorations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.70449","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:24:56Z","timestamp":1789496696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4418-171X","authenticated-orcid":false,"given":"Ana Catarina Rios Castro","family":"Alves","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Universidade Federal de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9622-3425","authenticated-orcid":false,"given":"Adonias Antonio","family":"da Silva","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universidade Federal de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3498-6756","authenticated-orcid":false,"given":"Roberta Bruno","family":"da Silva","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universidade Federal de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8242-1712","authenticated-orcid":false,"given":"Rayan","family":"de Lima Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universidade Federal de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7884-1657","authenticated-orcid":false,"given":"Dayse Andrade","family":"Rom\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universidade Federal de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4166-5546","authenticated-orcid":false,"family":"de Fragoso","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universidade Federal de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1811-2927","authenticated-orcid":false,"given":"Natanael Barbosa","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universidade Federal de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0908-7424","authenticated-orcid":false,"family":"de Porto","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universidade Federal de Alagoas Macei\u00f3 Alagoas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.dental.2016.11.015","article-title":"Academy of Dental Materials Guidance on in Vitro Testing of Dental Composite Bonding Effectiveness to Dentin\/Enamel Using Micro\u2010Tensile Bond Strength (\u03bcTBS) Approach","volume":"33","author":"Armstrong S.","year":"2017","journal-title":"Dental Materials"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.foodchem.2017.05.023","article-title":"Quercetin and Related Flavonoids Conserve Their Antioxidant Properties Despite Undergoing Chemical or Enzymatic Oxidation","volume":"234","author":"Atala E.","year":"2017","journal-title":"Food Chemistry"},{"issue":"2","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.dental.2018.11.029","article-title":"Evidence to the Role of Interflavan Linkages and Galloylation of Proanthocyanidins at Sustaining Long\u2010Term Dentin Biomodification","volume":"35","author":"Aydin B.","year":"2019","journal-title":"Dental Materials"},{"issue":"7","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1016\/j.actbio.2012.02.022","article-title":"The Dentin Organic Matrix \u2013 Limitations of Restorative Dentistry Hidden on the Nanometer Scale","volume":"8","author":"Bertassoni L. 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