{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:27:57Z","timestamp":1770971277312,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"MSIT","doi-asserted-by":"publisher","award":["NRF\u20102020R1F1A1049150"],"award-info":[{"award-number":["NRF\u20102020R1F1A1049150"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although several studies have investigated effective treatments for masticatory muscle pain (MMP), no unified conclusion has been drawn regarding the effectiveness of these treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to define quantitative indicators for predicting the outcome of MMP treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In total, patients aged 20\u201370 years were recruited and divided into the MMP (<jats:italic>n<\/jats:italic>\u2009=\u200924) and control (<jats:italic>n<\/jats:italic>\u2009=\u200936) groups, based on the presence of MMP according to the Diagnostic Criteria for Temporomandibular Disorders. At pretreatment, the MMP group was assessed using quantitative indicators such as subjective pain levels, pain duration, graded chronic pain scale (GCPS), and perceived stress scale (PSS). Salivary alpha\u2010amylase (sAA) and interleukin\u20106 (IL\u20106) levels were analyzed. The masticatory muscle palpation score and the range of mouth opening were measured. At posttreatment, subjective pain levels, mouth opening, and treatment\/medication duration were examined. The PSS and sAA levels were assessed in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>sAA levels in the MMP group were significantly higher than those in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The masseter muscle palpation score (MPS) showed a positive correlation with IL\u20106 levels (\u03c1\u2009=\u20090.503, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) and a negative correlation with nonsteroidal anti\u2010inflammatory drug (NSAID) treatment period (\u03c1\u2009=\u2009\u22120.462, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The temporalis muscle palpation score (TPS) was positively correlated with pain duration and GCPS grade (\u03c1\u2009=\u20090.483, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05, and \u03c1\u2009=\u20090.445, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with NSAIDs was effective in the MMP group with high MPS and IL\u20106 levels, but not in the MMP group with high TPS, pain duration, and GCPS grade.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.705","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T09:14:41Z","timestamp":1671786881000},"page":"219-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Establishment of quantitative indicators for an efficient treatment on masticatory muscle pain"],"prefix":"10.1002","volume":"9","author":[{"given":"Sunhee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Dental and Life Science Institute Pusan National University  Yangsan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye\u2010Min","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Dental and Life Science Institute Pusan National University  Yangsan Republic of Korea"},{"name":"Dental Research Institute, Pusan National University Dental Hospital  Yangsan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byong\u2010Sop","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Statistics Graduate School of the Pusan National University  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Hee","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Dental and Life Science Institute Pusan National University  Yangsan Republic of Korea"},{"name":"Dental Research Institute, Pusan National University Dental Hospital  Yangsan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Woo","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Dental and Life Science Institute Pusan National University  Yangsan Republic of Korea"},{"name":"Dental Research Institute, Pusan National University Dental Hospital  Yangsan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1776-371X","authenticated-orcid":false,"given":"Soo\u2010Min","family":"Ok","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Dental and Life Science Institute Pusan National University  Yangsan Republic of Korea"},{"name":"Dental Research Institute, Pusan National University Dental Hospital  Yangsan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-097X","authenticated-orcid":false,"given":"Kyounga","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2470547017704763"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01833.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2019.06.019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050474"},{"key":"e_1_2_10_6_1","first-page":"243","article-title":"Posttraumatic stress disorder symptoms and chronic orofacial pain: An empirical examination of the mutual maintenance model","volume":"23","author":"Burris J. 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