{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:02:24Z","timestamp":1787169744992,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to determine the severity of pain after endodontic treatment of mandibular molars with irreversible pulpitis following the use of sodium hypochlorite (NaOCl) at different temperatures and concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized, controlled clinical trial, 72 patients with mandibular molars with irreversible pulpitis were randomly assigned to six groups. The teeth were anesthetized and the root canals were prepared. During the instrumentation, the root canals were irrigated with NaOCl solution at concentrations of 0.5% and 1% and temperatures of 2.5\u00b0C, 22\u00b0C, and 40\u00b0C, 2.5\u00b0C were achieved through cryotherapy. Assessment of pain was conducted before, immediately after, and 3, 24, 48, and 72\u2009h after treatment. After obturation, the patients recorded their pain intensity at different time intervals on the visual analog scale (VAS) and reported the number of analgesics tablets they used. The frequency of analgesics tablets and their effect on pain sensation was recorded in the second part of the form. Repeated measures two\u2010way analysis of variance test was used to compare the trend of pain changes over time between two intervals of time in each group. Friedman's nonparametric test was used to compare the intragroup mean score of pain over time and Kruskal\u2013Wallis for comparing the intergroup mean score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Changes in VAS pain scores of all the groups were significant over time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Pain in all the groups decreased immediately after treatment and increased 3\u2009h after treatment. There were no significant differences in pain ratings and the number of analgesics tablets used in the groups of NaOCl with different concentrations and temperatures over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the study's limitations, we concluded that there was no significant difference between concentrations of 0.5%, and 1% and temperatures of 2.5\u00b0C, 22\u00b0C, and 40\u00b0C in pain intensity following endodontic treatment of mandibular molars with irreversible pulpitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.754","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T14:32:48Z","timestamp":1687617168000},"page":"859-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effect of different concentrations and temperatures of sodium hypochlorite irrigation on pain intensity following endodontic treatment of mandibular molars with irreversible pulpitis: A randomized, double\u2010blind clinical trial"],"prefix":"10.1002","volume":"9","author":[{"given":"Hadi","family":"Mokhtari","sequence":"first","affiliation":[{"name":"Department of Endodontic, Faculty of Dentistry Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0024-2494","authenticated-orcid":false,"given":"Amin Salem","family":"Milani","sequence":"additional","affiliation":[{"name":"Department of Endodontic, Faculty of Dentistry Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Zand","sequence":"additional","affiliation":[{"name":"Department of Endodontic, Faculty of Dentistry Tabriz University of Medical Sciences Tabriz 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