{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:00:49Z","timestamp":1740175249851,"version":"3.37.3"},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this technical report is to present two novel experimental implant designs to boost data generation in preclinical in vivo research. Specifically, the report describes the rationale and the components of (1) a two\u2010piece experimental implant suitable for a small animal platform (e.g., the rabbit femur\/tibial epiphysis model), consisting of a threaded apical\u2010 and a coronal cylindrical piece, which is intended for collecting\u00a0two\u00a0types\u00a0of biomechanical data, and (2) a three\u2010piece experimental implant suitable for a large animal platform (e.g., the mini\u2010pig mandible model), consisting of an apical \u201cwound chamber\u201d, which allows the collection of histological\/histomorphometrical data, and\u00a0a middle threaded\u00a0and\u00a0coronal cylindrical piece, which also allow the collection of\u00a0two\u00a0types of biomechanical data. The increased volume of information generated from a single experiment in a small animal platform, using the proposed two\u2010piece implant design, may assist in a more qualified decision\u2010making process, on whether it is relevant to proceed to further assessment using a large animal platform. Furthermore, the increased volume of information generated in a single animal experiment either in a small or large animal platform, using the proposed two\u2010 and three\u2010piece implants, respectively, likely decreases the number of animals otherwise needed for collecting the same information with standard one\u2010piece implants and, thus, contributes to the reduction\/refinement elements of the 3R principle.<\/jats:p>","DOI":"10.1002\/cre2.805","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T11:29:29Z","timestamp":1698751769000},"page":"1004-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two\u2010 and three\u2010piece implants to boost data generation in preclinical in vivo research\u2014A short technical report"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-3754","authenticated-orcid":false,"given":"Andreas","family":"Stavropoulos","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Odontology Malm\u00f6 University  Malm\u00f6 Sweden"},{"name":"Division of Conservative Dentistry and Periodontology, University Clinic of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Bellon","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry University of Zurich  Zurich Switzerland"},{"name":"Preclinical &amp; Translational Research Institut Straumann AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-5555","authenticated-orcid":false,"given":"Benjamin","family":"Pipenger","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"},{"name":"Preclinical &amp; Translational Research Institut Straumann AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole Z.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"},{"name":"Preclinical &amp; Translational Research Institut Straumann AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01827.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780429439964-32"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"117","article-title":"A human histologic analysis of osseotite and machined surfaces using implants with 2 opposing surfaces","volume":"19","author":"Lazzara R. 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S.","key":"e_1_2_10_6_1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12065"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T05:52:57Z","timestamp":1704261177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,31]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/cre2.805"],"URL":"https:\/\/doi.org\/10.1002\/cre2.805","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"type":"print","value":"2057-4347"},{"type":"electronic","value":"2057-4347"}],"subject":[],"published":{"date-parts":[[2023,10,31]]},"assertion":[{"value":"2023-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}