{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:49:29Z","timestamp":1785797369520,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The goal of this study is to measure and compare the hormonal serum levels (estrogen, progesterone, testosterone, prolactin, dihydrotestosterone [DHT]) in trigeminal neuroglia (TN) menopausal women and healthy women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This cross\u2010sectional and case\u2010control study was performed in 2018 and 2019. For this study, menopausal women with confirmed TN were enrolled. Twenty\u2010two healthy women in the control group and 19\u00a0in the case group participated. Blood samples were\u00a0taken from participants for assessment of hormonal serum levels (estrogen, progesterone, testosterone, prolactin, DHT). Data were analyzed by SPSS version 18. Mann\u2212Whitney, <jats:italic>T<\/jats:italic>\u2010test, kormography test, nonmetric, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0test, and odds ratios have been used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with TN, the serum level of testosterone was significantly higher (<jats:italic>p<\/jats:italic>\u2009=\u2009.036), and the serum level of prolactin (<jats:italic>p<\/jats:italic>\u2009=\u2009.016) was significantly lower. Other evaluated hormones'\u00a0serum level was identical in the two groups. Patients with abnormal estrogen levels were more in the TN group in comparison with the healthy group. The abnormality of progesterone in TN patients was more in comparison to the healthy control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Estrogen and progesterone serum levels in TN patients are higher in comparison with the healthy group, while prolactin and testosterone serum levels are lower in the control group. Moreover, the DHE serum level is similar in both groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.815","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T06:45:54Z","timestamp":1701240354000},"page":"1200-1205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of the serum level of estrogen, progesterone, prolactin, and testosterone in patients with trigeminal neuralgia compared to a healthy population"],"prefix":"10.1002","volume":"9","author":[{"given":"Fatemeh","family":"Lavaee","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Disease Department, Oral and Dental Disease Research Center, School of Dentistry Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Didar","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Dentistry Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2079-4317","authenticated-orcid":false,"given":"Aylar","family":"Afshari","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Dentistry Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2013.3555"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/670528"},{"key":"e_1_2_10_4_1","first-page":"105","volume-title":"Multiple sclerosis","author":"Baulieu E. 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