{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:23:29Z","timestamp":1793294609516,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study assessed the effectiveness of prehydrated collagenated xenogenic bone gel and a collagenated cortico\u2010cancellous heterologous bone mixture in conjunction with papillae tunneling techniques (PTT) for treating isolated periodontal intraosseous defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty patients with periodontitis stage III\/IV and at least one deep isolated interdental 2\/3\u2010wall intraosseous defect were included in the study. Surgical incisions were made vertically at the adjacent tooth or horizontally at the mucogingival junction. A full\u2010thickness flap was then carefully lifted under the papillae using special tunneling instruments. The root surfaces were completely cleaned, and the defects were randomly filled with either prehydrated collagenated bone gel (test group; <jats:italic>n<\/jats:italic>\u2009=\u200910) or collagenated cortico\u2010cancellous heterologous bone mixture (control group; <jats:italic>n<\/jats:italic>\u2009=\u200910). Wounds were closed with microsurgical sutures. We predicted that the lower 95% confidence interval for the difference between the two procedures would exceed a prespecified noninferiority threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All wounds closed sufficiently to prevent biomaterial exposure. The test and control groups showed similar mean pocket depth reduction (3.5\u2009\u00b1\u20091.0\u00a0vs. 3.9\u2009\u00b1\u20091.7\u2009mm; <jats:italic>p<\/jats:italic>\u2009=\u20090.52), similar gingival recession (\u22120.10\u2009\u00b1\u20090.99\u00a0vs. 0.2\u2009\u00b1\u20090.8\u2009mm; <jats:italic>p<\/jats:italic>\u2009=\u20090.46), and similar clinical attachment gain (3.6\u2009\u00b1\u20091.51\u00a0vs. 3.7\u2009\u00b1\u20091.8\u2009mm; <jats:italic>p<\/jats:italic>\u2009=\u20090.89) at the 12\u2010month follow\u2010up. All results were below the noninferiority margin of the sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At 12 months, prehydrated collagenous bone gel performed similarly to collagenous heterologous bone granules in the treatment of intraosseous lesions with PTT. In addition, both biomaterials preserved soft tissue with minimal further recession at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Relevance<\/jats:title><jats:p>When combined with PTT, collagenous xenogeneic bone granules and prehydrated collagenous bone gel achieve comparable clinical outcomes in intrabony defects.\u00a0The study was registered under the NCT 04782921 on ClinicalTrails.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.853","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T06:58:08Z","timestamp":1707289088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prehydrated collagenated cortico\u2010cancellous heterologous bone gel and papillae tunneling for isolated intrabony defects: 12\u2010month noninferiority trial"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8403-4097","authenticated-orcid":false,"given":"Tom","family":"Kobe","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Periodontology University Medical Centre Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Pov\u0161i\u010d","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontology University Medical Centre Ljubljana Slovenia"},{"name":"Department of Oral Medicine and Periodontology, Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rok","family":"Ga\u0161per\u0161i\u010d","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontology University Medical Centre Ljubljana Slovenia"},{"name":"Department of Oral Medicine and Periodontology, Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2584"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13255"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0288"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203771587"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01705.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.12.1702"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26051339"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma14051096"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13639"},{"issue":"2","key":"e_1_2_10_11_1","first-page":"S77","article-title":"Periodontal regeneration:\u00a0Intrabony defects: A systematic review from the AAP regeneration workshop","volume":"86","author":"Kao R. T.","year":"2015","journal-title":"Journal of Periodontology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2204240212"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/786353"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb13040276"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.3195"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04256-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0405"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.12.1485"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12946"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2220102.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.410"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00885.x"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T15:04:31Z","timestamp":1707750271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cre2.853"],"URL":"https:\/\/doi.org\/10.1002\/cre2.853","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e853"}}