{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:47:47Z","timestamp":1777164467723,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to assess the clinical and radiographic outcomes of non\u2010instrumentation endodontic treatment (NIET) using a modified antibiotic mix of cefixime, ciprofloxacin and metronidazole with simvastatin (an anti\u2010inflammatory, bone regeneration drug) on necrotic primary molars compared to conventional pulpectomy to help preservation of necrotic primary teeth until its natural exfoliation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Forty mandibular primary second molars with necrotic pulp tissue from 38 healthy patients aged between 4 and 8 years were randomly assigned to two groups with a 1:1 allocation ratio. Group A teeth underwent conventional root canal treatment. The procedure involved a two\u2010visit approach, employing k\u2010files and h\u2010files during the initial visit, followed by the application of calcium hydroxide paste as canal dressing between visits, while Group B teeth were treated with 3Mixtatin. All teeth were clinically evaluated after 1, 3, 6, and 12 months, and radiographically at 3, 6, and 12 months. Two external examiners assessed the results. Data analysis was conducted using a chi\u2010square test at a 0.05 significance level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of the follow\u2010up interval, 90% of teeth in each group exhibited no clinical signs or symptoms. Additionally, inter\u2010radicular radiolucency healing occurred in 75% of cases in the NIET group and 89.5% in the conventional pulpectomy group. However, no statistically significant difference was found between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NIET using 3Mixtatin seems to be a good alternative choice to conventional pulpectomy, offering a less complex treatment approach that may help avoid the complications associated with traditional pulpectomy and could be suitable for teeth with shorter roots.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.860","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T04:19:53Z","timestamp":1709525993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the modified 3Mix\u2010Simvastatin combination in non\u2010instrumental endodontic therapy of necrotic primary molars: A two\u2010arm randomized controlled trial"],"prefix":"10.1002","volume":"10","author":[{"given":"Walaa","family":"Almarji","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Damascus University Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohannad","family":"Laflouf","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Damascus University Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5498-9991","authenticated-orcid":false,"given":"Yasser Alsayed","family":"Tolibah","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Damascus University Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCD.JCD_76_20"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.17796\/1053-4628-40.2.95"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"8","article-title":"Simvastatin versus calcium hydroxide direct pulp capping of human primary molars: A randomized clinical trial","volume":"7","author":"Aminabadi N. 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A.","year":"2020","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2002.00482.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4034\/PBOCI.2015.151.22"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03415-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-60826-8.00034-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.17796\/1053-4625-42.5.7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.37.2.e5131jp6m1w33v66"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-2216"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/JISPPD.JISPPD_6_19"},{"key":"e_1_2_10_17_1","unstructured":"May J. E.(2016).A pilot study to compare clinical and radiographic success of a non\u2010root instrumentation non\u2010vital pulpotomy and a traditional pulpectomy.University of Birmingham."},{"issue":"1","key":"e_1_2_10_18_1","article-title":"Lesion sterilization and tissue repair of primary molar to the eruption of its permanent successor: A case report","volume":"25","author":"Moreira C. 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