{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:33:31Z","timestamp":1789763611776,"version":"4.0.1"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The response of the host to plaque can be affected by systemic diseases like diabetes, hormonal changes, or immunological deficits, which can hasten the progression and severity of periodontitis. This study aimed to compare the activity of salivary matrix metalloproteinase\u20108 (MMP\u20108) in patients with moderate to severe generalized chronic generalized periodontitis between healthy individuals and those with type 2 diabetes who were referred to the Tabriz School of Dentistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>For this cross\u2010sectional study, 90 patients were randomly divided into three groups based on inclusion and exclusion criteria: patients with chronic\u00a0generalized periodontitis with diabetes, patients with generalized chronic periodontal disease with normal blood glucose, and a control group of 30 healthy individuals. Participants were instructed not to brush their teeth for 12\u2009h and not to eat or drink for 90\u2009min before saliva sampling. Saliva samples were immediately stored at \u221280\u00b0C and analyzed using an ELISA test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that there was a significant difference in salivary MMP\u20108 levels among the three groups. Patients with periodontitis and diabetes had the highest levels of salivary MMP\u20108, while the control group had the lowest levels. This indicates that chronic generalized periodontitis is strongly associated with the activity level of salivary MMP\u20108, and elevated levels of MMP\u20108 in diabetic patients demonstrate the impact of diabetes on periodontal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the importance of monitoring salivary MMP\u20108 levels in patients with periodontitis, especially those with diabetes. It also emphasizes the need for proper management of systemic diseases to prevent or slow down the progression of periodontal disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.865","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T04:19:40Z","timestamp":1709525980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparing the activity level of salivary matrix metalloproteinase\u20108 in patients with diabetes and moderate to severe chronic generalized periodontitis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3297-5465","authenticated-orcid":false,"given":"Fatemeh","family":"Tavakoli","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Medicine Department, School of Dentistry Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1162-0507","authenticated-orcid":false,"given":"Masoumeh","family":"Faramarzi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Salimnezhad","sequence":"additional","affiliation":[{"name":"School of Dentistry Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-7611","authenticated-orcid":false,"given":"Bahare","family":"Jafari","sequence":"additional","affiliation":[{"name":"School of Dentistry Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-5872","authenticated-orcid":false,"given":"Hosein","family":"Eslami","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Medicine Department, School of Dentistry Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-114X","authenticated-orcid":false,"given":"Bardia","family":"MohammadPourTabrizi","sequence":"additional","affiliation":[{"name":"School of Dentistry Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7891323"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.128476"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207441"},{"issue":"2","key":"e_1_2_11_5_1","first-page":"268","article-title":"Low\u2010level laser therapy and changes in salivary proinflammatory cytokines: A systematic review","volume":"11","author":"Baljani F.","year":"2023","journal-title":"Journal of Health Sciences & Surveillance System"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2718-7"},{"issue":"4","key":"e_1_2_11_7_1","first-page":"S135","article-title":"Effect of periodontal disease on diabetes: Systematic review of epidemiologic observational evidence","volume":"84","author":"Borgnakke W. 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