{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:43:11Z","timestamp":1780461791464,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The bone regeneration therapy is often used in patients with inadequate bone support for implants, particularly following tooth extractions. Xenografts derived from animal tissues are effective bone reconstructive options that resist resorption and pose a low risk of transmitting disease. Therefore, these implants may be a good option for enhancing and stabilizing maxillary sinuses. The purpose of this study was to compare two xenografts, Bone<jats:sup>+<\/jats:sup>B\u00ae and InterOss\u00ae, for the reconstruction of rabbit calvaria defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>The study involved seven male New Zealand white rabbits. In the surgical procedure, 21 spots were created on both sides of the midline calvarium by creating three 8\u2010millimeter defects. A control group was used, as well as two treatment groups utilizing Bone<jats:sup>+<\/jats:sup>B\u00ae Grafts and InterOss\u00ae Grafts. After 3 months, the rabbits were euthanized, followed by pathological evaluation. Analysis of these samples focused on bone formation, xenograft remaining material, and inflammation levels, using Adobe Photoshop CS 8.0 and SPSS version 24.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With the application of Bone<jats:sup>+<\/jats:sup>B\u00ae graft, bone formation ranged from 32% to 45%, with a mean of 37.80% (\u00b15.63), and the remaining material ranged from 28% to 37%, with a mean of 32.60% (\u00b13.65). Using InterOss\u00ae grafts, bone formation was 61% to 75%, the mean was 65.83% (\u00b14.75), and the remaining material was 9% to 18%, with a mean of 13.17% (\u00b13.06). The bone formation in the control group ranged from 10% to 25%, with a mean of 17.17% (\u00b16.11). InterOss\u00ae had lower inflammation levels than other groups, but the difference was not statistically significant (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>InterOss\u00ae bone powder is the best option for maxillofacial surgery and bone reconstruction. This is due to more bone formation, less remaining material, and a lower inflammation level. Compared to the control group, Bone<jats:sup>+<\/jats:sup>B\u00ae improves healing and bone quality, thus making it an alternative to InterOss\u00ae.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.875","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T06:50:25Z","timestamp":1716792625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparing the effects of Bone<sup>+<\/sup>B\u00ae xenograft and InterOss\u00ae xenograft bone material on rabbit calvaria bone defect regeneration"],"prefix":"10.1002","volume":"10","author":[{"given":"Afshin Yadegari","family":"Naini","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry (Khorasgan) Isfahan Azad University Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepehr","family":"Kobravi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tehran medical sciences Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Jafari","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry (Khorasgan) Isfahan Azad University Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadhassan","family":"Lotfalizadeh","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology North Khorasan University of Medical Sciences Bojnurd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-5498","authenticated-orcid":false,"given":"Narges","family":"Lotfalizadeh","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Ferdowsi University of Mashhad Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareh","family":"Farhadi","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; 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